摘要
目的探讨江阴市妊娠梅毒流行特征以及新生儿梅毒干预后结局。方法通过收集2014年1月-2015年12月江阴市妊娠梅毒孕产妇的资料,进行回顾性分析。结果 2014-2015年全市累计对25 360例孕产妇进行了妊娠梅毒的血清学筛查,筛查出83例妊娠合并梅毒孕产妇,阳性率为3.27‰(83/25 360),孕期梅毒检测率为78.86%(20 000/25 360),孕产妇梅毒规范治疗率为72.29%(60/83)。单因素分析结果显示,患者年龄、户籍、职业、文化程度、经济收入、性伴侣数、婚姻情况、性伴侣是否梅毒患者8个因素为孕产妇感染梅毒的相关影响因素(χ~2=12.170~417.172,均P<0.05);经Logistic回归分析结果显示,户籍、职业、文化程度、经济收入、性伴侣数、婚姻情况、性伴侣是否梅毒患者7个因素为孕产妇感染梅毒的独立影响因素(χ~2=7.724~15.586,均P<0.05)。梅毒感染孕产妇所生的79例新生儿,先天梅毒儿6例(7.59%),出生梅毒反应阳性10例(12.66%),出生梅毒血清反应阴性63例(79.75%),对这些新生儿进行治疗、追踪随访,6例先天梅毒儿经治疗后,1个月内临床症状消失,出生梅毒反应阳性新生儿经预防性治疗后快速血浆反应素环状卡片试验(RPR)滴度均在9月龄内转阴。结论 2014-2015年江阴市妊娠梅毒仍主要在流动人口、低收入、低学历、性伴侣紊乱的人群中流行,近年来全市重视预防、筛查及治疗,已初显成效,孕产妇梅毒治疗率高,新生儿预后明显改善,今后将进一步提高妊娠梅毒的筛查,加强宣教,规范治疗,进一步改善妊娠梅毒患者的母婴预后。
Objective To discuss the epidemiological characteristics of pregnant women with syphilis and neonatal outcomes after intervention in Jiangyin City. Methods Data of pregnant women with syphilis in Jiangyin was collected from January 2014 to December2015 and analyzed retrospectively. Results Serological screening for syphilis was performed on totally 25 360 pregnant women from 2014 to2015,and 83 cases of syphilis were screened out. Positive rate was 3. 27‰（ 83/25 360）. Detection rate of syphilis during pregnancy was78. 86%（ 20 000/25 360）,and standardized treatment rate of pregnancy syphilis was 72. 29%（ 60/83）. Single factor analysis showed that age,household registration,occupation,educational level,economic income,sexual partner number,marital status and syphilis infection status of sex partner were eight influencing factors of pregnant women with syphilis（ χ^2value ranged 12. 170 to 417. 172,all P〈0. 05）. Logistic regression analysis showed that household registration,occupation,educational level,economic income,sexual partner number,marital status,and syphilis infection status of sex partner were seven independent influencing factors of pregnancy syphilis infection（ χ^2value ranged 7. 724 to 15. 586,all P〈0. 05）. There were 6 infants with congenital syphilis（ 7. 59%）,10 infants with syphilis positive reaction（ 12. 66%） and 63 infants with negative serological syphilis reaction（ 79. 75%） in 79 newborns of pregnant women with syphilis. With treatment and follow-up of these neonates,clinical symptom of 6 cases of congenital syphilis disappeared within1 month. RPR titers of infants with positive syphilis reaction turned to negative in 9 month age after preventive treatment. Conclusion Pregnant syphilis is still primarily popular in floating population and those with low income,low education and disordered sexual partner in Jiangyin from 2014 to 2015. Prevention,screening and treatment of pregnant syphilis are focused by municipal government in recent years and its exertion h
出处
《中国妇幼健康研究》
2017年第2期114-117,共4页
Chinese Journal of Woman and Child Health Research
关键词
妊娠合并梅毒
江阴市
流行病学特征
新生儿梅毒
pregnancy combined with syphilis
Jiangyin City
epidemiological characteristics
neonatal syphilis
