摘要
目的:探讨血清抑制素B(InhB)用于评价成年隐睾患者术后睾丸功能恢复的临床价值。方法:收集2011年10月~2015年9月于我科就诊的138例成年隐睾患者作为观察组,另收集100例健康志愿者作为正常对照组。用双抗体夹心酶联免疫吸附法检测观察组患者术前、术后30天和90天及正常对照组的血清InhB水平,并参照WHO人类精液检查与处理实验室手册(第五版)方法进行精液常规检查。结果:与正常对照组比较,观察组患者术前、术后30天和90天血清InhB水平、精子活率、精子密度均明显降低,差异均有统计学意义(P<0.05)。观察组术后30天血清InhB水平、精子活率、精子密度与术前比较差异均无统计学意义(P>0.05),观察组术后90天血清InhB水平、精子活率、精子密度明显高于术前,差异均有统计学意义(P<0.05)。观察组组术前、术后30天和90天的精液量与正常对照组对比差异均无统计学意义(P>0.05)。观察组术前、术后30天和90天及正常对照组血清InhB水平与精子浓度均呈正相关(观察组术前:r=0.81,P<0.05,观察组术后30天:r=0.78,P<0.05,观察组术后90天:r=0.84,P<0.05,正常对照组:r=0.77,P<0.05)。结论:血清InhB用于评估成年隐睾患者术后睾丸功能恢复具有一定的临床应用价值。
Objective： To investigate the clinical value of serum InhB in the evaluation of testicular function recovery of adult patients after cryptorchidism surgery. Methods： A retrospective study was performed on 138 patients with cryptorchidism（observation group） and 100 healthy persons（control group）. Double-antibody sandwich enzyme-linked immunosorbent assay was used to detect the levels of InhB in serum of patients（preoperation and 30, 90 d postoperation） and healthy persons. Semen parameter according to WHO laboratory manual for the examination and processing of human semen was deteted. Results： The levels of serum InhB, sperm motility and sperm density preoperation and on the 30 th, 90 th day postoperation of observation group were obviously lower than those of the control group（P〈0.05）. The levels of serum InhB, sperm motility and sperm density on the 30 th day postoperation and preoperation of observation group showed no significant difference（P〉0.05）. The levels of serum InhB, sperm motility and sperm density on the 90 th day postoperation of observation group were obviously higher than those of observation group preoperation（P〈0.05）. The levels of ejaculation sperm volume of observation group（preoperation and 30, 90 d postoperation） and control group showed no statistical significance（P〉0.05）. The levels of serum InhB was positively correlated with the sperm density of observation group（preoperation and 30, 90 d postoperation） and control group（observation group preoperation： r=0.81, P〈0.05, observation group 30 d postoperation： r=0.78, P〈0.05, observation group 90 d postoperation： r=0.84, P〈0.05, control group： r=0.77, P〈0.05）. Conclusion： InhB level could be helpful to evaluate the recovery of testicular function after cryptorchidism surgery of adult patients.
出处
《现代生物医学进展》
CAS
2017年第2期363-365,392,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81170400)
关键词
血清抑制素B
隐睾
睾丸
功能
Inh B
Cryptorchidism
Testicle
Function recovery
