摘要
目的研究经支气管镜药物灌注治疗难治性空洞型肺结核患者的临床疗效。方法纳入我院2013年12月-2015年12月难治性空洞型肺结核患者94例随机均等分为两组。常规组采用单纯全身化疗治疗,试验组采用经支气管镜药物灌注治疗。比较两组患者的毒副作用发生情况和血尿常规、肝肾功能变化;治疗前和治疗后患者生存质量水平的差异。结果试验组病灶吸收率、痰菌转阴率、空洞闭合率比常规组高,P〈0.05;试验组、常规组治疗过程毒副作用发生情况均比较轻微,无严重毒副反应,且均无血尿常规、肝肾功能异常,治疗前两组生存质量水平相似,P〉0.05;治疗后试验组相较于常规组生存质量水平改善更显著,P〈0.05。结论经支气管镜药物灌注治疗难治性空洞型肺结核患者的临床疗效确切,可有效促进病灶吸收、痰菌转阴和空洞闭合,提升患者生存质量,且无严重毒副反应,安全性较高,患者可耐受。
Objective To study the clinical efficacy of endoscopic drug perfusion in refractory cavitary pulmonary tuberculosis. Methods A total of 94 patients with refractory cavitary tuberculosis were enrolled in our hospital from December 2013 to December 2015, and were randomly divided into two groups. The patients in the routine group were treated with simple systemic chemotherapy. The patients were treated with bronchoscopy. The two groups of patients with toxic and side effects and hematuria routine, liver and kidney function changes,and before and after treatment, the quality of life differences in patients were compared. Results The rate of lesion, sputum negative rate and empty closure rate were higher in the experimental group than in the conventional group,P〈0.05. The incidence of side effects in the treatment group and the conventional group were mild and no serious side effects were observed. The quality of life of the two groups was similar to that of the conventional group,P〉0.05. The quality of life was significantly higher in the experimental group than in the conventional group,P〈0.05. Conclusion The clinical efficacy of bronchoscopic drug infusion in the treatment of refractory idiopathic tuberculosis is effective, which can effectively promote the absorption of the lesion, the sputum negative and empty closure, improve the quality of life of patients, and no serious toxic and side effects, The patient can tolerate.
出处
《中国卫生标准管理》
2016年第36期56-58,共3页
China Health Standard Management
