摘要
乳腺癌为中国女性最常见的恶性肿瘤之一,近几十年呈逐渐高发趋势。除早期手术切除以及放化疗等传统方法外,内分泌治疗和靶向治疗已成为分子分型乳腺癌治疗的常规手段。乳腺癌治疗仍然伴随易转移、易复发、易产生抗性和毒副作用大等特点。细胞凋亡阻断是包括乳腺癌在内的恶性肿瘤的最大特征。探讨乳腺癌细胞凋亡信号通路异常分子机制,诱导其重新进入凋亡周期可能是治愈乳腺癌的最根本途径。本文通过对近5年来关键细胞凋亡信号通路在诱导乳腺癌凋亡中的研究进行分析总结,进一步明确这些信号通路在乳腺癌治疗中的作用,以期找到乳腺癌治疗的特异性分子靶点。
Breast cancer is one of the most common malignant tumors in Chinese women. In last decades, the incidence and mortality of breast cancer showed a gradual upward trend. In addition to conventional treatment including early stage resection and ra- dio/ehemo-therapy, endocrine therapy and molecular target therapy have been the standard regime for molecular typing breast cancer. However, these malignancies treatment is usually along with recurrence, metastasis, resistance, high toxicity and side effects. Apopto- sis blockage is the hallmark of human cancers including breast eaneer. Understanding the deregulation mechanisms of apoptosis signal pathway and inducing breast cancer into apoptosis are the most fundamental approach to cure these diseases. This study has summarized the research advances of key apoptotic signal pathways in breast cancer. We hope to explicit the roles of those apoptotic signal pathways and find out the specific molecular target in breast caneer treatment.
作者
赵相轩
温锋
卢再鸣
ZHAO Xiangxuan WEN Feng LU Zaiming(Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China)
出处
《临床肿瘤学杂志》
CAS
2017年第2期175-179,共5页
Chinese Clinical Oncology
基金
国家自然科学基金面上资助项目(31371425)
国家自然科学基金主任专项基金资助项目(31240025)
辽宁省自然科学基金资助项目(2013023056)
关键词
乳腺癌
细胞凋亡
靶向药物
信号转导
Breast cancer
Cell apoptosis
Target drug
Signal transduction
