摘要
目的探讨肿瘤异常蛋白(TAP)在非小细胞肺癌(NSCLC)中的临床价值。方法202例肺部结节患者,根据术后病理分成NSCLC组(102例)和肺良性病变组(100例),测定患者外周血中TAP的表达。结果 NSCLC组TAP阳性表达率为73.53%,高于肺良性病变组的10.00%(P<0.01)。在NSCLC组中,腺癌和鳞状细胞癌的TAP阳性表达率分别为72.73%和78.57%。在肺良性病变组中,炎性结节、结核结节和不典型增生的TAP阳性表达率分别为4.62%、10.00%和33.33%。结论 NSCLC患者血清TAP表达量明显高于肺良性病变者,检测TAP表达有助于肺部病变性质的鉴别判断。
Objective To investigate the expression and significance of tumor abnormal protein（TAP）in the patients with non-small cell lung cancer（NSCLC）.Methods According to postoperative pathological diagnosis,202 patients with pulmonary nodules were divided into two groups of A（with NSCLC,102cases）and B（with benign lung lesions,100cases）.Serum levels of TAP expression were detected in two groups.Results The positive expression rate of TAP was higher in group A than that in group B（73.53% vs.10.00%）（P〈0.01）.The expression rates of TAP in the patients with adenocarcinoma and squamous cell carcinoma in group A were 72.73% and 78.57%,which in the patients with inflammatory nodules,tuberculous nodules and atypical hyperplasia in group B were4.62%,10.00% and 33.33%,respectively.Conclusion Serum level of TAP expression in the patients with NSCLC is significantly higher than those with benign pulmonary lesions.Detection of serum TAP is helpful in the identification of benign and malignant pulmonary lesions.
出处
《江苏医药》
CAS
2017年第4期248-249,共2页
Jiangsu Medical Journal
基金
江苏省干部保健科研课题(BJ13012)
关键词
肿瘤异常蛋白
非小细胞肺癌
肺部结节
Tumor abnormal protein
Non-small cell lung cancer
Pulmonary nodules
