摘要
目的武汉市第九医院探讨A型肉毒素治疗机体瘢痕增生的临床疗效和安全性。方法 2014年6月—2015年6月,我科共收治80例增生性瘢痕患者,随机分为观察组和对照组,每组40例,对照组采用曲安奈德局部注射治疗,观察组采用A型肉毒素局部注射治疗,比较2组临床疗效,病理表现,并观察复发情况和不良反应发生情况。结果观察组总有效率高于对照组,组间差异有统计学意义(P<0.05);与治疗前相比,2组治疗1~5次后,瘢痕长轴逐渐缩短,组内差异均有统计学意义(P<0.05);治疗前两组瘢痕长轴长度差异无统计学意义(P>0.05);每个时间点观察组瘢痕长轴长度短于对照组,组间差异均有统计学意义(P<0.05);2组不良反应发生率无统计学意义(P>0.05);6个月内,观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论 A型肉毒素治疗机体瘢痕增生临床疗效佳,不良反应少,具有广阔的临床应用前景。
Objective In order to investigate the efficacy and safety of botulinum toxin type A on body scar treatment.Methods Eighty cases of hypertrophic scars from June 2014 to June 2015 in our department were randomly divided into two groups, observation group（40 cases） and control group（40 cases）. The control group were received local injection of triamcinolone acetonide for treatment while the observation group were treated with local injection of botulinum toxin type A,several indexes were investigated including clinical efficacy, pathology, and recurrence and adverse effects. Results The total efficiency of observation group was higher than that of control group, and the difference between the two groups was statistically significant（P〈0.05）. Compared with before treatment, after treatment for 1 to 5 times, the long axis of scar was shorting gradually, and the difference between the two groups was statistically significant（P〉0.05）. The difference between the two groups in terms of length of scar＇s long axis before treatment showed no statistically significant（P〈0.05）; the length of scar axis in observation group at each time point were shorter than the control group, and the difference between the two groups was statistically significant（P〈0.05）. The incidence of adverse reactions between the two groups showed no significant difference（P〉0.05）. Within six months, the recurrence rate in observation group was lower than that in control group, the difference was statistically significant（P〈0.05）. Conclusion Botulinum toxin type A on treatment of body scar has good clinical efficacy with less adverse effects, and it has a broad clinical application.
作者
刘斌
李静
胡惠清
Liu Bin Li Jing Hu Huiqing(The Ninth Hospital of Wuhan City in HuBei Province, Wuhan 430080, Chin)
出处
《中国中西医结合皮肤性病学杂志》
CAS
2017年第1期25-27,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
关键词
肉毒素
瘢痕增生
曲安奈德
临床疗效
不良反应
Botox
Scar
Triamcinolone acetonide
Clinical efficacy
Adverse effects
