摘要
目的观察中西医结合及早期康复训练治疗新生儿缺氧缺血性脑病临床疗效。方法 2012年1月至2015年1月庆阳市中医医院儿科收治住院的中、重度HIE患儿152例,随机分为观察组和对照组各76例。对照组早期均进行吸氧、镇静、利尿、降颅压、有效控制惊厥等对症支持治疗,病情稳定后给予注射用脑蛋白水解物和单唾液酸四己糖神经节苷脂注射液静脉滴注。观察组在对照组治疗的基础上运用中医辨病辨证依据加用中药治疗并进行早期康复训练。日龄3d、14d、28d做神经行为评分(NBNA),评价两组患儿治疗前后NBNA评分;分别于3、6、9、12、18个月时作智能发育测定;治疗结束时观察比较两组临床疗效。结果观察组总有效率为92.1%(70/76),高于对照组78.9%(60/76),差异有统计学意义(P<0.05)。两组治疗后NBNA评分均较治疗前明显改善,差异有统计学意义(P<0.05);观察组治疗后NBNA评分均高于对照组,差异有统计学意义(P<0.01)。两组治疗后发育商评分均较治疗前明显改善,差异有统计学意义(P<0.01),观察组发育商评分改善较对照组更显著,差异有统计学意义(P<0.01)。结论中西医结合及早期康复训练治疗新生儿缺氧缺血性脑病疗效确切。
Objective To observe the clinical effect of integrated traditional Chinese and Western medicine and early rehabilitation training in the treatment of neonatal hypoxic ischemic encephalopathy.Methods Totally 152 cases of hypoxic ischemic encephalopathy were randomly divided into treatment group and control group,76 cases in each group.In the early stage,oxygen inhalation,sedation,dieresis,intracranial pressure reduction,control of seizures and other symptomatic support therapies were given in both of the groups.In the stable stage,patients in the control group were given cerebroprotein hydrolysate for injection and monosialo four hexose ganglioside injection.In the treatment group,besides cerebroprotein hydrolysate for injection and monosialo four hexose ganglioside injection,patients were given traditional Chinese medicine treatment based on pattern differentiation and early rehabilitation training.NBNA was performed on 3d,14 dand 28drespectively and compare the NBNA of the two groups before and after treatment.Intelligence development was determined respectively at 3,6,9,12 and 18months.Observe and compare the clinical effect in the two groups after treatment.Results The total effective rate was 92.1%in the treatment group,and 78.9%in the control group,the difference of which was statistically significant（P〈0.05）.The NBNA was significantly improved in the two groups after treatment,and the difference was of statistical significance（P〈0.05）.The NBNA was higher in the observation group than in the control group with statistical difference（P〈0.01）.After treatment the development score was significantly improved in both groups,and there was statistical difference compared with that before treatment（P〈0.01）,the score improvement was more significant in the observation group,the difference being statistically significant（P〈0.01）.Conclusion The combination of traditional Chinese and Western medicine and early rehabilitation training is effective in the treatment of neonatal hypoxic ischemi
作者
赵书琳
魏丽芳
ZHAO Shulin WEI Li fang(Qingyang TCM Hospital ,Qingyang 745000 ,Chin)
出处
《中国中西医结合儿科学》
2017年第1期57-60,共4页
Chinese Pediatrics of Integrated Traditional and Western Medicine
关键词
缺氧缺血性脑病
中西医结合
早期康复训练
婴儿
新生
Integrated medicine
Early rehabilitation training
Neonatal hypoxic ischemic encephalopathy
Baby
newborn
