摘要
目的探讨糖尿病肾病(DN)不同中医证型核因子-κB(NF-κB)通路相关细胞因子的表达差异及其临床意义。方法选取该院146例DN患者,按中医辨证进行分型,检测血清中肿瘤坏死因子α(TNF-α)及白细胞介素(IL)-1、IL-6、IL-8水平,并与62例健康体检者(对照组)比较。结果不同中医证型DN各组的TNF-α、IL-1、IL-6及IL-8水平比较,均高于对照组,差异有统计学意义(P<0.05)。各个证型DN患者中TNF-α、IL-1、IL-6及IL-8水平比较,差异有统计学意义(P<0.05)。随着DN病程进展,各细胞因子水平均呈逐步升高的趋势,且DN不同证型升高的幅度与时间不一致。结论 NF-κB通路相关细胞因子TNF-α、IL-1、IL-6及IL-8与DN不同中医证型具有相关性,可能在DN不同证型的发生、发展中起一定的作用。
Objective To explore the expression difference of cytokines related to nuclear factor kappa B（NF-κB）signaling pathway among different traditional Chinese medicine（TCM）syndromes in the patients with diabetic nephropathy（DN）.Methods Serum tumor necrosis factor-α（TNF-α）,interleukin-1（IL-1）,interleukin-6（IL-6）and interleukin-8（IL-8）in 146 patients with DN and 62 individuals undergoing healthy physical examination in the control group were measured.Results The levels of serum TNF-α,IL-1,IL-6and IL-8in various DN groups were significantly higher than those in the control group（P〈0.05）.The levels of serum TNF-α,IL-1,IL-6and IL-8were significantly different among groups of different TCM syndromes（P〈0.05）.With the progression of DN,all cytokines levels showed a gradually increasing trend,moreover the increased extents and time were different in different TCM syndrome types of DN.Conclusion The levels of serum TNF-α,IL-1,IL-6and IL-8related to NF-κB signaling pathway are correlated with different TCM syndromes types and may play a role in the occurrence and progression of different TCM syndrome types of DN.
出处
《重庆医学》
CAS
北大核心
2017年第7期898-900,共3页
Chongqing medicine
基金
佛山市医学类科技攻关项目(2014AB00287)
关键词
糖尿病肾病
NF-ΚB
细胞信号通路
细胞因子类
中医证型
diabetic nephropathy
NF-kappa B
cell signaling pathway
cytokines
traditional Chinese Medicine syndrome
