摘要
目的探讨红细胞脆性、MCV、MCH、Hb A2在诊断地中海贫血中的应用价值。方法采用回顾性分析的方法 ,分析同时进行地中海贫血筛查及基因诊断的930例患者的检查结果,并将其分为对照组、贫血组、α-地贫组和β-地贫组。结果地贫组与贫血组在MCV和MCH方面差异无统计学意义(P>0.05),在红细胞脆性方面差异有统计学意义(P<0.05);ROC曲线下的面积中,α-地贫组中所有参数的面积均未达到90%,β-地贫组中红细胞脆性和Hb A2的面积均达到90%,而MCV和MCH的面积较小;红细胞脆性、MCV、MCH、Hb A2在α-地贫组中的最佳诊断截断值分别为:50.50、71.65、23.25、2.65,在β-地贫中的最佳诊断截断值分别为48.50、71.05、23.10、3.55。结论红细胞脆性、MCV、MCH、Hb A2四个参数在诊断地中海贫血方面有一定的作用,多个参数综合考虑可为临床诊断地中海贫血提供更准确的参考依据。
Objective To explore the clinical value of erythrocyte fragility, MCV, MCH and HbA2 in the diagnosis of thalassemia. Methods The examination results of 930 patients with thalassemia screening and gene diagnosis in our hospital were analyzed retrospectively, and all cases were divided into control group, anemia group, alpha thalassemia group and beta thalassemia group. Results There was no statistically difference in MCV and MCH between thalassemia group and anemia group, but there was a significant difference in erythrocyte fragility （P 〈0.05）. The areas of ROC curve did not reach 90% in alpha thalassemia group, but the areas of ROC curve reached 90% in erythrocyte fragility and HbA2 of beta thalassemia group, and the areas of ROC curve were smaller in MCV and MCH. The cutoff values were 50.50, 71.65, 23.25, 2.65 respectively in erythrocyte fragility, MCV, MCH, HbA2 of alpha thalassemia group, and 48.50, 71.05, 23.10, 3.55 in beta thalassemia group. Conclusions Erythrocyte fragility, MCV, MCH and HbA2 have certain value in the diagnosis of the thalassemia, which will provide a more accurate reference for clinical diagnosis ofthalassemia.
出处
《临床医学工程》
2017年第2期181-182,共2页
Clinical Medicine & Engineering
基金
广东省中医药局科研项目"绿茶提取物靶向HIF-α的抗阿尔茨海默病Aβ生成及其机制的研究"(项目编号:20161092)
