摘要
目的了解伴有自杀行为的抑郁症和不伴有自杀行为的抑郁症之间是否存在遗传差异。方法用家族史法对124例伴有自杀行为的抑郁症和115例不伴有自杀行为的抑郁症患者进行研究,用多基因阈值理论估算遗传率和标准误。结果伴有自杀行为的抑郁症患者的一级亲属精神疾病患病率,一级亲属及一至三级亲属抑郁症患病率分别为9.64%、6.63%、1.86%,均显著高于不伴有自杀行为的抑郁症患者(均P<0.05);伴有自杀行为的抑郁症的加权平均遗传率及标准误为(44.51±1.01)%,显著高于不伴有自杀行为的抑郁症患者(u=5.46,P<0.01)。结论伴有和不伴有自杀行为的抑郁症患者的遗传效应之间存在遗传差异。
Objective To determine whether there is a difference in the genetic effects between patients of unipolar depression with suicidal behavior and those without suicidal behavior. Method 124 cases of unipolar depression with suicidal behavior and 115 cases without suicidal behavior were studied with the method of family history. The heritahility was estimated with multiple gene threshold theory. Findings The prevalence rate of those diagnosed as cases of depression with suicidal behavior in the first-degree relatives and one to three relatives were 9.64% , 6.63% , 1.86% , which were higher than those （4. 87% , 3. 76% , 1. 23% ） without suicidal behavior （ all P 〈 0. 05）. The weighted mean of the heritability and standard error of those with suicidal behavior was （44.51 ± 1.01 ）% , which was significantly higher than that of those without suicidal behavior （ u = 5.46, P 〈 0.01 ）. Conclusion There are differences in genetic effects between patients of unipolar depression with suicidal behavior and those without suicidal behavior.
出处
《健康研究》
CAS
2017年第1期74-76,共3页
Health Research
关键词
抑郁症
自杀行为
遗传效应
家族
depression
suicidal behavior
genetic effects
