摘要
炎症小体(inflammasome)是一类胞浆内大分子多蛋白复合体,它能调节半胱氨酸天冬氨酸特异蛋白酶1(caspase-1)的活化,促进白细胞介素(interleukin,IL)-1β和IL-18成熟与分泌,引起炎症反应。尽管大部分炎症小体激活的具体分子机制尚不明确,但是最近NLRC4炎症小体越来越为人们所知。NLRC4炎症小体参与机体的固有免疫应答,在多种病原体感染过程中发挥重要的免疫调控作用。本文将对NLRC4炎症小体的构成、活化机制以及在微生物感染中的作用作一概述。
Inflammasomes comprise a family of cytosolic multi-protein complex that can regulate the secretion of IL-1β and IL-18,and initiate inflammation via the recruitment and activation of the caspase-1.While the mechanisms of activation of most inflammasomes are unclear,the NLRC4 subfamily of inflammasomes is increasingly well understood.NLRC4 Inflammasome participates in the body＇s innate immune response and plays an important role in immune regulation after bacterial infection.Here,the component of NLRC4 Inflammasome,the mechanism of activation of NLRC4 Inflammasome and the effects of NLRC4 Inflammasome after infected with bacteria were reviewed.
出处
《中南医学科学杂志》
CAS
2017年第1期1-6,共6页
Medical Science Journal of Central South China
