摘要
目的建立兔耳实验性痤疮模型,观察各组兔耳痤疮组织病理学改变、皮肤肥大细胞改变及艾叶挥发油对模型兔的痤疮治疗作用。方法将2%煤焦油溶液外涂于家兔右耳内侧,2周后按实验步骤随机分为空白对照组、基质组、艾叶挥发油乳膏高、中、低浓度组和0.025%维A酸乳膏对照组共6组。在显微镜下观察各组兔耳痤疮组织病理学改变和皮肤肥大细胞改变。结果外涂煤焦油2周后,肉眼可见兔耳出现人类粉刺样改变;在光镜下呈现与人类痤疮类似的病理改变;肥大细胞数目明显增多,经艾叶挥发油治疗后有所减少。结论艾叶挥发油对实验性痤疮治疗效果较好,减轻炎症反应,减少肥大细胞数量。艾叶挥发油治疗痤疮的作用机制可能与抑制肥大细胞增殖、趋化及脱颗粒有关。
Objeetive In this study, we established an experimental acne model of rabbit ears, observed the histopathological changes of rabbit ear acne, the changes of shin mast cell and the effect of Artemisia volatile oil on acne in model rabbits. Methods 2 percent of coaltar solution coated on the inner ear in rabbits, after 2 weeks, according to the experimental procedure, the rabbits were randomly divided into Blank control groups, Matrix groups, Artemisia volatile oil of high, medium and low concentration groups, 0.025% dimensional A acid cream group, a total of six group. Under the microscope observed the histopathological changes of rabbit ear acne and the changes of shin mast cell. Results After 2 weeks of coal-tar oil, Visible to the naked eye of rabbit ear appear human kind acne change ; Under light microscopy show similar pathological changes likes human acne; The number of mast cells increased obviously, after the treatment of Artemisia volatile oil has decreased. Conclusion Artemisia volatile oil has an good effect on the experimental acne, reduced the inflammatory reaction, reduced the number of mast cells. In the treatment of acne the mechanism of Artemisia volatile oil is probably by inhibiting proliferation 、 chemotaxis and degranulation of mast cells.
出处
《云南中医学院学报》
2017年第1期18-21,32,共5页
Journal of Yunnan University of Traditional Chinese Medicine
基金
安徽中医药大学校级课题(2015zr012)
关键词
痤疮
艾叶挥发油
肥大细胞
acne
Artemisia volatile oil
mast cell
