摘要
目的:探讨用α-硫辛酸联合甲钴胺治疗2型糖尿病周围神经病变(DPN)的临床效果。方法:将我院2015年2月~2016年3月期间收治的63例2型糖尿病周围神经病变患者随机分为单一用药组与联合用药组,其中单一用药组有31例患者,联合用药组有32例患者。用甲钴胺对单一用药组患者进行治疗,用α-硫辛酸联合甲钴胺对联合用药组患者进行治疗。治疗结束后,观察对比两组患者的治疗效果与正中神经传导速度的改善情况。结果:联合用药组患者治疗的总有效率明显高于单一用药组患者,其正中神经传导的速度明显低于联合用药组患者,差异具有统计学意义(P<0.05)。结论:用α-硫辛酸联合甲钴胺治疗2型糖尿病周围神经病变效果显著,能明显地提高其正中神经的传导速度。
Objective ：Discussion α- lipoic acid and methylcobalamin clinical effect of type 2 diabetic peripheral neuropathy.Method ：The patients in our hospital in February 2015~March 2016 were treated 63 patients with type 2 diabetic peripheral neuropathy were randomly divided into control group（n=31,to give methyl cobalamin）and experimental group（n=32,to give methylcobalamin＋α-lipoic acid）,clinical efficacy of drugs after treatment 2 group and median nerve conduction velocity.Result ：Clinical drug efficacy in the control group（64.5%）was significantly lower than the experimental group（93.7%）in the control group median nerve conduction velocity（34.23 ± 3.14）m/s,lower than the experimental group（37.43±3.25）m/s.2 group,the difference was statistically significant（p〈0.05）.Conclusions ：Mecobalamin α-lipoic acid in the treatment of type 2 diabetic peripheral neuropathy significant effect,can increase the median nerve conduction velocity.
