摘要
目的探讨颅内压监测在1,2-二氯乙烷中毒性脑病患者应用甘露醇治疗中的应用价值。方法选择2009年1月至2016年1月期间收治的30例急性1,2-二氯乙烷中毒性脑病患者,根据随机数字表法随机分为两组,每组15例。对照组患者予常规甘露醇脱水降颅内压治疗,观察组在有创颅内压监测下应用甘露醇治疗,并根据监测结果调整甘露醇用法,比较两组患者治疗前后颅内压的变化及临床疗效。结果观察组与对照组患者治疗后颅内压分别为(148.6±14.3)mm Hg和(168.9±17.6)mm Hg,均较治疗前有明显下降,且观察组患者颅内压下降明显低于对照组,差异均有统计学意义(P<0.05);观察组患者的治疗总有效率为100.00%,明显高于对照组的90.00%,差异有统计学意义(P<0.05)。结论颅内压监测下对1,2-二氯乙烷中毒性脑病患者应用甘露醇治疗,可以根据患者颅内压的变化及时调整甘露醇的剂量,从而达到更好的治疗效果。
Objective To investigate the clinical value of intracranial pressure monitoring in patients with 1,2-dichloroethane toxic encephalopathy undergoing mannitol treatment.Methods A total of 30 patients with acute toxic encephalopathy,who admitted to our hospital from Jan.2009 to Jan.2016 were selected and randomly divided into the two groups according to the random number table,with 20 cases in each group.The control group was treated with mannitol;the observation group was treated with mannitol therapy under invasive intracranial pressure monitoring,and the use of mannitol was adjusted according to monitoring results.The changes of intracranial pressure and clinical effects were compared before and after treatment.Results After treatment,the intracranial pressure in observation group and control group were respectively（148.6±14.3） mm Hg and（168.9±17.6） mm Hg,which were significantly decreased than that before treatment,and the pressure in the observation group were significantly lower than that in the control group（P〈0.05）.The total effective rate in the observation group was 100.00%,which was significantly higher than 80.00% in the control group（P〈0.05）.Conclusion In the course of treating 1,2-dichloroethane toxic encephalopathy with mannitol therapy under intracranial pressure monitoring,the dose of mannitol can be adjusted according to changes of intracranial pressure,which help to achieve better therapeutic effect.
出处
《海南医学》
CAS
2017年第3期397-399,共3页
Hainan Medical Journal
关键词
颅内压监测
1
2-二氯乙烷中毒性脑病
甘露醇
疗效
Intracranial pressure monitoring
1
2-dichloroethane toxic encephalopathy
Mannitol
Curative effect
