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心脏再同步化治疗对合并左心室收缩功能不全的三度房室传导阻滞患者左心室重构的影响 被引量:4

Impact of Cardiac Resynchronization Therapy on Ventricular Remodeling in Patients With Ⅲ° Atrio-ventricular Block Combining Systolic Dysfunction
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摘要 目的 :旨在观察心脏再同步化治疗(CRT)对合并左心室收缩功能不全的三度房室传导阻滞(AVB)患者左心室重构的影响。方法 :选取2009-01至2014-10在本院接受CRT的三度AVB患者49例,分别于术前、术后6个月和12个月行超声心动图检查,测定左心室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、二尖瓣反流(MR)分级等多项指标,观察心脏结构及功能变化情况。结果 :49例患者术后LVEF逐渐上升,与术前相比,术后6个月LVEF增加(4.92±5.24)%(P<0.05),术后12个月LVEF较术后6个月进一步增加(5.02±6.52)%(P<0.05);LVESV较术前逐渐降低,术后6个月LVESV下降(25.02±17.95)ml(P<0.05),12个月时LVEVS较术后6个月进一步下降(24.79±22.49)ml(P<0.05);其他指标亦有改善,与术前相比,术后6个月LVEDV下降(25.61±24.24)ml(P<0.05),LVEDD下降(3.22±2.91)mm(P<0.05),LVESD下降(4.43±2.86)mm(P<0.05),MR分级下降(0.49±0.76)级(P<0.05),上述指标在术后12个月进一步降低,与术后6个月对比,LVEDV下降(28.18±22.36)ml(P<0.05),LVEDD下降(4.17±3.14)mm(P<0.05),LVESD下降(4.92±4.40)mm(P<0.01),MR分级下降(0.22±0.55)级(P<0.05)。结论 :CRT可逆转合并收缩功能不全的三度AVB患者的左心室重构,改善心功能。 Objective:To observe the impact of cardiac resynchronization therapy(CRT) on ventricular remodeling in patients with III°atrio-ventricular block(AVB) combining systolic dysfunction.Methods:A total of 49 III°AVB patients received CRT in our hospital from 2009-01 to 2014-10 were studied.Echocardiography was conducted at pre-operation and 6,12 months post-operation to measure left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD) and mitral regurgitation(MR) grade in order to observe the changes of cardiac structure and function in relevant patients.Results:Compared with pre-operative condition,at 6 months post-operation,LVEF was increased(4.92±5.24) % and at 12 months post-operation,it was further increased(5.02±6.52) %,both P0.05;at 6 months post-operation,LVESV reduced(25.02±17.95) ml and at 12 months post-operation,it was further reduced(24.79±22.49) ml,both P0.05.Compared withpre-operative condition,at 6 months post-operation,LVEDV dropped(25.61±24.24) ml,LVEDD dropped(3.22±2.91) mm,LVESD dropped(4.43±2.86) mm and MR grade dropped 0.49±0.76,all P0.05.Compared with 6 months post-operation,at 12 months post-operation,LVEDV declined(28.18±22.36) ml,LVEDD declined(4.17±3.14) mm,both P0.05,LVESD declined(4.92±4.40) mm,P0.01 and MR grade declined(0.22±0.55),P0.05.Conclusion:CRT may reverse ventricular remodeling and improve cardiac function in patients with III°AVB combining systolic dysfunction.
出处 《中国循环杂志》 CSCD 北大核心 2017年第1期54-57,共4页 Chinese Circulation Journal
基金 2013年安徽省科技攻关计划项目(1301042210) 安徽省第八批"115"产业创新团队
关键词 心脏再同步化治疗 房室传导阻滞 心室重构 Cardiac resynchronization therapy Atrio-ventricular block Ventricular remodeling
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