摘要
目的 :旨在观察心脏再同步化治疗(CRT)对合并左心室收缩功能不全的三度房室传导阻滞(AVB)患者左心室重构的影响。方法 :选取2009-01至2014-10在本院接受CRT的三度AVB患者49例,分别于术前、术后6个月和12个月行超声心动图检查,测定左心室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、二尖瓣反流(MR)分级等多项指标,观察心脏结构及功能变化情况。结果 :49例患者术后LVEF逐渐上升,与术前相比,术后6个月LVEF增加(4.92±5.24)%(P<0.05),术后12个月LVEF较术后6个月进一步增加(5.02±6.52)%(P<0.05);LVESV较术前逐渐降低,术后6个月LVESV下降(25.02±17.95)ml(P<0.05),12个月时LVEVS较术后6个月进一步下降(24.79±22.49)ml(P<0.05);其他指标亦有改善,与术前相比,术后6个月LVEDV下降(25.61±24.24)ml(P<0.05),LVEDD下降(3.22±2.91)mm(P<0.05),LVESD下降(4.43±2.86)mm(P<0.05),MR分级下降(0.49±0.76)级(P<0.05),上述指标在术后12个月进一步降低,与术后6个月对比,LVEDV下降(28.18±22.36)ml(P<0.05),LVEDD下降(4.17±3.14)mm(P<0.05),LVESD下降(4.92±4.40)mm(P<0.01),MR分级下降(0.22±0.55)级(P<0.05)。结论 :CRT可逆转合并收缩功能不全的三度AVB患者的左心室重构,改善心功能。
Objective:To observe the impact of cardiac resynchronization therapy(CRT) on ventricular remodeling in patients with III°atrio-ventricular block(AVB) combining systolic dysfunction.Methods:A total of 49 III°AVB patients received CRT in our hospital from 2009-01 to 2014-10 were studied.Echocardiography was conducted at pre-operation and 6,12 months post-operation to measure left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD) and mitral regurgitation(MR) grade in order to observe the changes of cardiac structure and function in relevant patients.Results:Compared with pre-operative condition,at 6 months post-operation,LVEF was increased(4.92±5.24) % and at 12 months post-operation,it was further increased(5.02±6.52) %,both P0.05;at 6 months post-operation,LVESV reduced(25.02±17.95) ml and at 12 months post-operation,it was further reduced(24.79±22.49) ml,both P0.05.Compared withpre-operative condition,at 6 months post-operation,LVEDV dropped(25.61±24.24) ml,LVEDD dropped(3.22±2.91) mm,LVESD dropped(4.43±2.86) mm and MR grade dropped 0.49±0.76,all P0.05.Compared with 6 months post-operation,at 12 months post-operation,LVEDV declined(28.18±22.36) ml,LVEDD declined(4.17±3.14) mm,both P0.05,LVESD declined(4.92±4.40) mm,P0.01 and MR grade declined(0.22±0.55),P0.05.Conclusion:CRT may reverse ventricular remodeling and improve cardiac function in patients with III°AVB combining systolic dysfunction.
出处
《中国循环杂志》
CSCD
北大核心
2017年第1期54-57,共4页
Chinese Circulation Journal
基金
2013年安徽省科技攻关计划项目(1301042210)
安徽省第八批"115"产业创新团队
关键词
心脏再同步化治疗
房室传导阻滞
心室重构
Cardiac resynchronization therapy
Atrio-ventricular block
Ventricular remodeling