摘要
目的:加强替加环素使用的规范管理,评价其用药的合理性,为临床合理用药提供参考。方法:抽取我院2014年6月—2015年6月应用注射用替加环素(泰阁)的出院患者病例,从病原学检查、药物敏感性试验、用法用量、疾病类型等方面对105例病例进行评价分析。结果:我院应用注射用替加环素的药物利用指数(DUI)值为1.075;105例病例中,102(97.14%)例行病原学检查,76例(72.38%)有药敏试验结果;65例(61.90%)有2种以上混合感染;83例(79.05%)符合说明书给药剂量。结论:医疗机构需要对注射用替加环素的使用进行严格管理,并对其给药疗程、剂量及处方权限加以控制,防止经验性用药,减少耐药的发生。
Objective： To strengthen regulation of tigecycline use management,and evaluate the medication rationality,for providing a reference for clinically rational drug use. Methods： Data of 105 discharged patients who had been treated with injectable tigecycline（ Thai Pavilion） in our hospital in June 2014 to June 2015 were collected,and evaluated in aspects of pathogenic examination,drug susceptibility testing,usage,dosage,and type of disease. Results： In our hospital,the DUI for injectable tigecycline was 1. 075. In the 105 patients,102 had pathologic examination,accounting for 97. 14%; 76 had DST results,accounting for 72. 38%; 65 had mixed infection of two or more,accounting for 61. 90%; 83 were in line with the instructions of the administered dose,accounting for 79. 05%. Conclusion： Medical institutions need strict management for tigecycline use,and should control their course of administration,dosage and prescription privileges to prevent empiric treatment and reduce resistance.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2017年第4期476-480,共5页
Chinese Journal of New Drugs
关键词
替加环素
合理用药
耐药性
tigecycline
rational drug use
drug resistance
