摘要
目的研究产程中静滴不同剂量缩宫素对新生儿发生病理性黄疸的影响。方法选取嘉兴市妇幼保健院2014年8月～2015年9月妊娠足月的产妇生产的足月正常的具有催产特征的新生儿386例,参照孕妇产程中使用缩宫素剂量的不同,分为低剂量组（2.5～5.0U,n=96）,中剂量组（5.0～7.5U,n=96）,高剂量组（7.5～10.0U,n=96）,同时选取不使用缩宫素的产妇作为对照组（n=98）。记录各组产妇年龄、总产程时间、新生儿性别、新生儿体质量以及出生七天内的胆红素值。研究每组新生儿患有病理性黄疸的几率与缩宫素剂量之间的关系。结果新生儿发生病理性黄疸,低剂量组发病率为3.23%,中剂量组为6.67%,高剂量组为29.73%,对照组为3.16%。低、中剂量组与对照组比较发病率差异无统计学意义;低、中剂量组,对照组与高剂量组比较差异均有统计学意义（P〈0.05）。结论产程中,使用总量〈7.5 U的缩宫素对新生儿患有病理性黄疸无显著影响,〉7.5 U可增加新生儿发生病理性黄疸的几率。
Objective To study the effects of different oxytocin doses on neonatal pathologic jaundice.Methods A total of 386 newborn infants with normal term of labor were selected from the full-term pregnant women who were admitted to Jiaxing Maternal and Child Health Care Hospital from August 2014 to September 2015 were divided into low dose group（2.5~5.0U,n=96）,middle dose group（5.0~7.5U,n=96）,high dose group（7.5~10.0U,n=96） and control group（n=98） according to the different dosage of oxytocin.Total labor time,neonatal gender,neonatal weight and maternal age,as well as the day of birth within seven days of skin side of the bile values were recorded.The probability of each group of neonatal patients with pathological jaundice and the relationship with oxytocin doses were studied.Results The incidence of neonatal pathologic jaundice was 3.23% in the low dose group,6.67% in the middle dose group,29.73% in the high dose group and 3.16% in the control group.The differences among low dose group,middle dose group and control group were not significan.Compared with high dose group,the incidence of neonatal pathologic jaundice in low dose group,middle dose group,and the control group were all lower（P〈0.05）.Conclusion Oxytocin less than 7.5U in labor has no significant effect on neonatal pathologic jaundice, 7.5U can promote pathologic jaundice.
出处
《中国生化药物杂志》
CAS
2017年第2期159-161,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
浙江省医学会临床科研资金项目(2013ZYC-B6)
