摘要
目的探讨艾迪对宫颈癌术后放化疗致心脏损伤的保护作用。方法收集舟山医院肿瘤科收治的宫颈癌患者74例,已完成宫颈癌手术,并根据术后分期以及病例分型分别予以放化疗治疗,随机将患者分为试验组和对照组,每组各37例。对照组予以止吐以及升白细胞治疗;试验组在对照组的基础上予以艾迪注射液100 mL静脉滴注,每天1次。2组均以10天为1个疗程,共治疗6个疗程。治疗结束后,比较2组患者心功能状况、左室射血分数、左室舒张末内径、6分钟步行试验、心肌酶谱、肌钙蛋白T、C反应蛋白/生活质量评分Barhel指数、EORTC-QLQ评分以及不良反应发生情况。结果治疗后,试验组心功能状况明显优于对照组（P〈0.05）。治疗后,2组患者LVEDD均下降（P〈0.05）,LVEF、6分钟步行试验距离升高（P〈0.05）,且试验组较对照组LVEDD更低（P〈0.05）,LVEF、6分钟步行试验距离更高（P〈0.05）。治疗后,2组肌酸激酶同工酶以及肌酸激酶水平较治疗前升高（P〈0.05）;且试验组肌酸激酶同工酶以及肌酸激酶水平较对照组高（P〈0.05）。治疗后,2组肌钙蛋白T、C反应蛋白水平较治疗前降低（P〈0.05）;且试验组肌钙蛋白T、C反应蛋白水平较对照组更低（P〈0.05）。治疗后,2组生活质量评分Barhel指数以及EORTCQLQ评分显著高于治疗前（P〈0.05）,且试验组生活质量评分Barhel指数以及EORTC-QLQ评分水平显著高于对照组（P〈0.05）。2组不良反应发生比较差异无统计学意义。结论艾迪对宫颈癌术后放化疗致心脏损伤有较为明显的保护作用,且能够提高患者的生活质量。
Objective To investigate the protective effect of Addie on cardiac injury induced by radiotherapy and chemotherapy in patients with cervical cancer.Methods 74 cases of cervical cancer were collected from the oncology department of Zhousha Hospital,those were treated with surgery and radiotherapy and chemotherapy according to postoperative staging and classification of cases.The patients were randomly divided into the experimental group and the control group,with 37 cases in each group.Control group received leukogenic and antiemetic treatment,the experimental group were given Addie injection 100 mL intravenous drip on the basis of the control group,one times per day,10 days as one courses,and two groups were all received 6 courses of treatment.Atthe end of treatment,the condition of heart function,left ventricular ejection fraction,left ventricular end diastolic diameter,6 minutes walk test,myocardial enzymes,troponin T,C reactive protein/Barhel quality of life score index,EORTC-QLQ score and the incidence of adverse reactions were detected and compared with two groups.Results After treatment,the cardiac function of the experimental group was significantly better than that of the control group（P〈0.05）.After treatment,LVEDD of two groups decreased（P〈0.05）,LVEF,6 minutes walk test distance increased（P〈0.05）,and LVEDD of experimental group was lower than control group（P〈0.05）,LVEF,6 minutes walk test distance higher（P〈0.05）.After treatment,creatine kinase and creatine kinase levels were increased in two groups（P〈0.05）.Compared with the control group,the level of creatine kinase and creatine kinase in experimental group were higher（P〈0.05）.After treatment,the levels of troponin T and C reactive protein in two groups were decreased（P〈0.05）.Compared with the control group,the levels of troponin T and C reactive protein in experimental group were lower（P〈0.05）.After treatment,the scores of Barhel index and EORTC-QLQ score of two groups were significantly higher than
出处
《中国生化药物杂志》
CAS
2017年第2期116-119,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
艾迪
宫颈癌
术后放化疗
心脏损伤
Addie
cervical cancer
postoperative radiotherapy and chemotherapy
heart injury
