摘要
目的 探讨顺铂联合多西紫杉醇同期放疗治疗晚期食管癌患者的临床疗效以及对患者免疫状态的影响。方法 选取东阳市人民医院于2011年1月-2014年6月收治的104例晚期食管癌患者,平均分为对照组和观察组,每组各52例。2组患者均给予三维适行放疗,总剂量55-65gy,疗程6w;同时,对照组患者给予顺铂（20mg/m2）联合5-氟尿嘧啶（400mg/m2）进行化疗,观察组患者给予顺铂（20mg/m2）联合多西紫杉醇（120mg/m2）进行化疗,疗程均3w。比较2组患者临床治疗效果、生存率及平均生存时间、不良反应发生率,并检测2组患者治疗前后免疫功能指标CD3＋、CD4＋、CD8＋和CD4＋/CD8＋水平。结果 观察组治疗总有效率为86.53%,对照组治疗总有效率为69.23%,差异有统计学意义（P〈0.05）;观察组患者2年生存率以及平均生存时间均显著优于对照组,差异有统计学意义（P〈0.05）;观察组不良反应发生率为59.62%,对照组不良反应发生率为65.38%,差异有统计学意义（P〈0.05）;治疗前2组患者免疫功能指标CD3＋、CD4＋、CD8＋和CD4＋/CD8＋水平无显著性差异,治疗后观察组患者CD3＋、CD4＋、CD8＋和CD4＋/CD8＋水平均显著优于对照组,差异有统计学意义（P〈0.05）。结论 三维适行放疗基础上给予顺铂联合多西紫杉醇化疗效果优于顺铂联合5-氟尿嘧啶化疗,且不良反应少,同时对晚期食管癌患者免疫功能的影响更小。
Objective To investigate the clinical effect and patients of docetaxel and cisplatin combined with radiotherapy for advanced esophageal carcinoma of the safety and the effect on the immune status of patients. Methods 104 cases o f advanced esophageal cancer patients admitted in Dongyang People＇s Hospital from January 2011 to June 2014 were divided into the control group and the observation group with 52 cases in each group. The two groups of patients were treated with three-dimensional conformal radiotherapy, total dose of 55 ~65gy, the course of treatment was six weeks, at the same time, the control group were treated with cisplatin （20mg/m2） combined with 5-fluorouracil （400mg/m2） chemotherapy, the observation group were treated with cisplatin （20mg/m2） combined with docetaxel （120mg/m2） chemotherapy, the course of treatment was three weeks. Compared the two groups of patients with clinical treatment efifect, survival rate and the average survival time, adverse reaction rate, and detection of two groups of patients before and after the treatment of immune function index CD3＋, CD4＋, CD8＋ and CD4＋/CD8＋ levels. Results The total effective rate of observation group was 86.53%, the total effective rate of control group was 69.23%, the difference was statistically significant （P〈 0.05）, the patients in the observation group two years survival rate and mean survival time were significantly better than the control group, the difference was statistically significant （P〈 0.05）, the adverse reaction rate of the observation group was 59.62%, the adverse reaction rate of the control group was 65.38%, the difference was statistically significant （P〈 0.05）, two patients immune function indexes of CD3＋, CD4＋, CD8＋ and CD4＋/CD8＋ levels had no significant difference before treatment after treatment, patients in the observation group, CD4＋, CD3＋, CD8＋and CD4＋/CD8＋ were significantly better than the control group, the difference was statistically significan
出处
《中国生化药物杂志》
CAS
2017年第1期226-228,232,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
晚期食管癌
顺铂
多西紫杉醇
联合
同期放疗
advanced esophageal carcinoma
cisplatin
docetaxel
combine
radiotherapy
