摘要
肾素血管紧张素系统(RAS)包括AngⅠ、AngⅡ及其相应受体AT1R、AT2R、肾素、ACE等,AngⅡ是RAS系统的主要活性物质,其各组分在骨组织上皆有所表达,在骨骼的生长、发育、代谢的过程中发挥着重要的调控作用。糖尿病性骨质疏松症是一种以骨量减少和骨组织微结构损毁为特征的骨骼疾病,是糖尿病最常见的并发症之一,也是致残率最高的疾病。目前治疗糖尿病性骨质疏松症都依托于已知的发病机制,但从长期的临床经验来看,这些治疗措施都存在很大的局限性,如价格昂贵、副作用大等。因此,我们需要进一步探索糖尿病性骨质疏松症发生、发展的病理机制,寻找潜在的治疗靶点,在防治方面有所突破。本文综述了肾素血管紧张素系统在糖尿病性骨质疏松症病程中的生物学作用,并就肾素血管紧张素对胰岛素抵抗、胰岛素抵抗对骨代谢、肾素血管紧张素对骨代谢、肾素血管紧张素拮抗剂对糖尿病性骨质疏松症四个方面进行重点阐述,为今后糖尿病性骨质疏松症的药物治疗提供依据。
Renin angiotensin system（ RAS） includes Ang I,Ang II,and their receptors AT1 R,AT2R,rennin,and ACE,et al.Ang II is the main active substances in RAS. They all express in the bone tissue,and play an important role in growth,development,and metabolism of the bone. Diabetic osteoporosis is a bone disease which is characterized by bone mass loss and microstructure damage of the bone. It is one of the most common complications of diabetes,with the highest disability rate. At present,the treatment of diabetic osteoporosis is based on the known pathogenesis,but from a long-term clinical experience,it has a lot of limitation,such as high price and more side effects,etc. Therefore,we need to further explore the mechanism of the occurrence and development diabetic osteoporosis,to look for potential therapeutic targets,and to break through in the prevention and treatment. This paper illustrates the role of RAS in diabetic osteoporosis from the aspect of biology. The paper also focuses on the effect of RAS on insulin resistance,insulin resistance on bone metabolism,RAS on bone metabolism,and RAS antagonists diabetic osteoporosis,which may contribute to future drug treatment.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2017年第1期112-115,140,共5页
Chinese Journal of Osteoporosis
