摘要
目的探讨新疆汉族、维吾尔族帕金森病(PD)患者血清中免疫球蛋白(IgG、IgA、IgM)及补体(C3、C4)水平是否具有差异。方法选择104例原发性帕金森病患者(PD组),其中汉族64例,维吾尔族40例;选择135例健康体检者为对照组,其中汉族84例,维吾尔族51例。采用特种蛋白分析仪检测血清中免疫球蛋白(IgG、IgA、IgM)及补体(C3、C4)的水平,分析汉族、维吾尔族PD患者的血清免疫球蛋白(IgG、IgA、IgM)、补体水平(C3、C4)是否存在差异及其与PD的关系。结果 PD组IgG值高于对照组(P<0.05)。维吾尔族PD组IgA值高于维吾尔族对照组(P<0.05)。汉族PD组与汉族对照组IgG、IgA、IgM、C3、C4值差异均无统计学意义(P>0.05),汉族PD与维族PD组各指标差异也无统计学意义(P>0.05)。将与总体PD相关的5个因素(IgG、IgA、IgM、C3、C4)进行Logistic回归分析提示,血清IgG每增加1个单位,PD的发生风险增加1.675倍(P=0.007,OR=1.675)。进一步将与汉族PD相关的5个因素(IgG、IgA、IgM、C3、C4)进行Logistic回归分析提示,血清IgG每增加1个单位,汉族PD的发生风险增加2.096倍(P=0.029,OR=2.096);但血清IgG水平与维族PD无关。结论 PD患者IgG值高于正常人;维吾尔族PD患者IgA值高于正常维吾尔族人;IgG可能是汉族PD的危险因素。
Objective To explore the difference of serum levels of immunoglobulin （ IgG, IgA,IgM） and complement （ C3, C4） in patientswith Parkinson＇ s disease（PD） between Han and Uygur nationality in Xinjiang province. Methods A total of 104 cases of primary Parkinson＇ s disease（ PD group） were selected, including 64 cases of Han nationality and 40 cases of Uygur nationality. Another 135 healthy controls were selected as control group, including 84 cases of Han nationality and 51 cases of Uygur nationality. The serum lev- els of immunoglobulins （IgG, IgA, IgM） and complements （C3, CA ） were detected by special protein analyzer, and their relationship with PD were analyzed. Results IgG level in PD group was statistically higher than in control group（ P 〈 0.05 ）. The serum level of lgA in Uygur PD patients was higher than that in Uygur controls （P 〈 0.05 ）. There was no significant difference in IgG, IgA, IgM, C3 and CA levels between Han PD group and Han control group （ P 〉 0.05 ） and between Han PD group and Uygur PD group （ P 〉 0.05 ）. Lo- gistic regression analysis of the five factors associated with PD（ IgG, IgA, IgM, C3, C4） showed that the risk of PD increased by 1. 675 times for each additional unit of IgG（P = 0. 007, OR = 1. 675 ）. And the Logistic regression analysis showed that the risk of PD in- creased by 2. 096 times in Han nationality （ OR = 2. 096, P = 0. 029 ）, however, the level of serum lgG was not associated with PD in Uygur nationality. Conclusion The lgG level is higher in PD patients than in normal controls. The IgA is higher in Uygur PD pa- tients than that of normal Uighurs. IgG may he a risk factor of PD in Han nationality.
出处
《山西医科大学学报》
CAS
2017年第2期156-160,共5页
Journal of Shanxi Medical University
基金
国家自然科学基金资助项目(U1503222)
