摘要
目的从指标性化学成分量变化的角度,考察不同干燥方式和条件对参蒲盆炎颗粒浸膏质量的影响,为干燥工艺的优选提供方法依据。方法参蒲盆炎颗粒浸膏分别采用带式真空干燥、喷雾干燥、板式减压干燥、常压干燥4种不同方式进行干燥,测定各干燥样品含水量及芍药苷、虎杖苷和延胡索乙素的量,分别采用方差分析、聚类分析与主成分分析方法比较各组样品中3种指标成分量的差异、聚类情况,确定与干燥工艺参数相关性最大的化学成分。结果不同干燥方式样品含水量差异小,芍药苷、虎杖苷、延胡索乙素的量存在较大差异,以带式真空干燥样品中各成分量最高,喷雾干燥次之,100℃常压干燥样品最低。其中,带式真空干燥、喷雾干燥对样品指标性成分破坏较小且聚为一类,而板式减压干燥、常压干燥对样品指标成分破坏较大,并各自聚为一类。芍药苷、虎杖苷和延胡索乙素的量对4种干燥工艺的参数变化均较为敏感,在干燥过程中应重点监测这几类物质的量变化。结论干燥方式和条件的改变对参蒲盆炎颗粒浸膏质量的影响不容忽视,指标性化学成分定量测定可作为评价参蒲盆炎颗粒浸膏干燥工艺优选的一种快速检测方法。
Objective From the viewpoint of content changes of chemical composition, the effects of different drying methods and conditions on the quality of extracts from Shenpu Penyan Granule（SPG） were investigated. Evidence was provided for the optimization of dessication technology. Methods Extracts from SPG were dried by belt vacuum drying, spray drying, plank decompression drying, and drying under normal pressure, respectively. The moisture capacity and contents of peoniflorin, polygonin and tetrahydropulmatine in samples by different drying methods were determined. The content differences of three indexes chemical constituents and the clustering conditions in different groups of samples were compared by analysis of variance and cluster analysis. The maximal correlation between the components and drying technology parameters was determined by principal component analysis. Results The moisture capacity of different dry extracts were similar to each other. The contents of peoniflorin, polygonin, and tetrahydropulmatine in samples by different drying methods were obviously different. Those components in samples prepared by belt vacuum drying were the highest, those by spray drying were the second highest, and those by drying under normal pressure at 100 ℃were the lowest. Cujus, the index chemical constituents in samples were destroyed minorly by belt vacuum drying and spray drying, while those were destroyed majorly by plank decompression drying and drying under normal pressure. The samples prepared by belt vacuum drying and spray drying were classified in the same group, while those prepared by plank decompression drying and drying under normal pressure were classified respectively in different groups. The contents of peoniflorin, polygonin, and tetrahydropulmatine were sensitive to the technology parameters change of four kinds drying methods, it was important to monitor the content change of the materies. Conclusion The effects of different drying methods and conditions on the quality of extracts from SPG should
出处
《中草药》
CAS
CSCD
北大核心
2017年第3期474-483,共10页
Chinese Traditional and Herbal Drugs
基金
科学技术部国家重大新药创制项目(2013ZX09402203)
关键词
参蒲盆炎颗粒
干燥方式
芍药苷
虎杖苷
延胡索乙素
带式真空干燥
喷雾干燥
板式减压干燥
常压干燥
含水量
方差分析
聚类分析
主成分分析
相关性
Shenpu Penyan Granule
drying method
peoniflorin
polygonin
tetrahydropulmatine
belt vacuum drying
spray drying
plank decompression drying
drying under normal pressure
moisture capacity
analysis of variance
cluster analysis
principal component analysis
correlation
