摘要
目的:评价经筋理论指导治疗膝骨关节炎的有效性和安全性。方法:计算机检索中国知网、中国生物医学文献数据库、维普、万方、Pub Med、The Cochrane Library等数据库,查找经筋理论指导治疗膝骨关节炎的随机对照试验(RCT),检索时间为从建库至2016年5月,按照纳入与排除标准独立筛选文献、提取资料和评价质量后,用Review Manager 5.3软件进行Meta分析。结果:共纳入16篇文献,共计1297例患者。Meta分析结果显示,经筋理论指导治疗膝骨关节炎在总有效率(RR=1.13,95%CI=[1.08,1.18],P<0.000 01)、治疗前后WOMAC疼痛评分差值(MD=2.47,95%CI=[2.05,2.90],P<0.000 01)、功能评分差值(MD=5.69,95%CI=[1.24,10.14],P=0.01)、总评分差值(MD=4.09,95%CI=[0.31,7.88],P=0.03)方面均优于传统疗法。而治疗前后WOMAC僵直评分差值方面,2种疗法差异无统计学意义(MD=0.06,95%CI=[-0.16,0.27],P=0.62)。结论:经筋理论指导治疗膝骨关节炎的疗效优于传统疗法,期待通过更多高质量、大样本、长期随访的RCT进一步验证其疗效。
Objective：To evaluate the efficacy and safety of the treatment of knee osteoarthritis by the musculature theory.Methods：A computer retrieval was done for randomized-controlled trials （ RCT ） treated by musculature theory from databases such as CNKI,CBM,VIP, Wanfang Data,PnbMed and The Cochrane Library （ from the database establishment to May.2016 ） .The retrieved literature was selected according to the inclusion and exclusion criteria, evaluated and Mata-analyzed with software Review Manager 5,3.Results：A total of 16 articles were selected,including a total of 1297 patients.Meta analysis results showed that treating knee osteoarthritis under the guidance of the musculature theory was better than the traditional methods on the aspects of efficiency （ RR = 1.13,95%CI = [ 1.08,1.18 ] ,P 〈 0.000 01 ） ,WOMAC Pain score difference before and after treatment （ MD = 2.47,95%CI = [ 2.05,2.90 ] ,P 〈 0.000 01 ） ,function score difference （ MD = 5.69,95%CI = [ 1.24,10.14 ] ,P = 0.01 ） ,and the total score difference （ MD = 4.09,95%CI = [ 0.31,7.88 ] ,P = 0.03 ） .The difference of WOMAC stiff scores before and after treatment had no statistically significant differences for the two kinds of therapies （ MD = 0.06,95%CI = [ -0. 1 6,P = 0.27 ] ,P = 0.62 ） .Conclusion：The treatment of knee osteoarthritis by the musculature theory is better than by the traditional therapy, and its efficacy is expected to be further verified by more RCT with high-quality, large sample and long-term follow-up.
出处
《风湿病与关节炎》
2017年第2期36-40,43,共6页
Rheumatism and Arthritis
基金
广东省中医优势病种突破项目(粤中医函〔2015〕19号)
关键词
骨关节炎
膝
经筋理论
疗效
系统评价
随机对照试验
META分析
osteoarthritis,knee
the musculature theory
efficacy
systematic evaluation
randomized controlled trials
Meta-analysis
