摘要
2013年初,中国部分城市和地区出现了禽流感病毒H7N9感染人的病例,截止目前已有超过500人感染H7N9,感染者死亡率约为30%。WHO专家预测,禽流感病毒H7N9可能引起大流行。因此,人用H7N9禽流感疫苗的研发刻不容缓。目前已有多个H7N9疫苗备选株通过了WHO安全性评价,可用于疫苗研发。在此基础上,H7N9灭活疫苗、减毒活疫苗以及重组疫苗均已取得较好的研究结果。本文对人用H7N9禽流感疫苗的研究进展作一综述。
In early 2013, a novel avian influenza virus（H7N9）strain was discovered in some parts of East China, which caused more than 500 cases of infection and a mortality of about 30% in humans. The experts of WHO predicted that the novel avian influenza virus（H7N9） strain may cause a pandemic, therefore the development of H7N9 vaccine is eagerly needed. At present, couples of candidate H7N9 vaccine strains have passed the safety evaluation by the WHO and may be used for the vaccine development. On the basis of this, satisfactory results have been obtained in the development of inactivated, live attenuated and recombinant avian influenza H7N9 vaccines. This paper reviews the progress in research on avian influenza H7N9 vaccine.
出处
《中国生物制品学杂志》
CAS
CSCD
2017年第2期210-214,共5页
Chinese Journal of Biologicals
基金
国家高技术研究发展项目("863"计划)项目(2012AA02A404)
国家科技部国际科技合作项目(2011DFR30420)
