摘要
目的:观察健脾益肾汤治疗晚期非小细胞肺癌的临床疗效。方法:将40例脾肾两虚证Ⅲb、Ⅳ期非小细胞肺癌(NSCLC)患者随机分为对照组、观察组各20例。对照组采用NP方案,观察组在对照组治疗的基础上服用健脾益肾汤,1剂/d,水煎早晚分服,连服21天。检测2组治疗前后循环肿瘤细胞(CTC),并评价临床疗效及生活质量(KPS)。结果:CTC治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后组间比较,差异也有统计学意义(P<0.05)。总有效率对照组为75.00%,观察组为85.00%,2组比较差异有统计学意义(P<0.05)。KPS改善情况2组比较差异有统计学意义(P<0.05)。结论:健脾益肾汤联合NP方案可明显减少晚期NSCLC患者外周血CTC数量,提高肿瘤缓解率和获益率,明显改善患者生活质量。
Forty patients with NSCLC of kidney and spleen deficiency in IIIb and IV period were randomly divided into the control group and the observation group, each group 20 cases. The control group was giv- en NP regimen, the observation group was given JianPi YiShen Tang on the treatment of the control group, one dose one day, morning and night administration by water decoction, continuous administration for 21 days. CTC were de- tected before and after treatment in both groups, clinical effects and KPS were evaluated. Results： There was statisti- cal difference between two groups before and after treatment in CTC （P〈0.05）; there was also statistical difference between two groups after treatment （P〈0.05）. The total effective rate was 75.00% in the control group, 85.00% in the observation group, there was statistical difference between two groups（P〈0.05）. There was statistical difference in KPS improvement between two groups （P〈0.05）. Conclusion： JianPi YiShen Tang combined with NP regimen can reduce C TC number of PB in advanced NSCLC, promote tumor remission rate and benefit rate, improve life quality of patients.
出处
《西部中医药》
2016年第12期77-80,共4页
Western Journal of Traditional Chinese Medicine
基金
陕西省教育厅专项科研计划项目(编号2013K0830)
