摘要
目的探讨盐酸托烷司琼联合地塞米松对化疗后乳腺癌患者术后不良反应的疗效。方法收集2014年3月—2015年1月我院乳腺癌根治术术后患者,两组化疗方案为环磷酰胺联合表柔比星。临床分期T1-3N1-2M0。分为:100例研究组和100例对照组。研究组采取盐酸托烷司琼联合地塞米松止吐。对照组采取盐酸托烷司琼止吐。对比(1)两组乳腺癌病理类型及病理分期。(2)两组化疗后胃肠道不良反应发生情况。结果 (1)两组乳腺癌病理类型及病理分期比较,差异无统计学意义(P>0.05)。(2)两组化疗后胃肠道不良反应(恶心、呕吐)比较,差异有统计学意义(P<0.05)。结论盐酸托烷司琼联合地塞米松可以减少乳腺癌患者术后化疗时的恶心呕吐感。
Objective To study the effect of postoperative chemotherapy combined with dexamethasone in patients with breast cancer after chemotherapy. Methods Patients with breast cancer after radical mastectomy were collected in our hospital from March 2014 to January 2015. The two groups were treated with cyclophosphamide combined with epirubicin. Clinical stage T1-3N1-2M0. There were 100 cases in study group and 100 cases in control group. The study group was treated with tropisetron hydrochloride combined with dexamethasone antiemetic. The control group took antiemetic tropisetron hydrochloride. Comparison：（1） Pathological type and pathological stage of breast cancer in the two groups.（2） The incidence of gastrointestinal adverse reactions after chemotherapy in the two groups. Results（1） There was no significant difference in pathological type and pathological stage of breast cancer between the two groups（P 〉 0.05）.（2） There was significant difference between the two groups in gastrointestinal adverse reactions（nausea and vomiting） after chemotherapy（P〈0.05）. Conclusion Combination of ondansetron hydrochloride and dexamethasone can reduce nausea and vomiting after chemotherapy in patients with breast cancer.
出处
《中国继续医学教育》
2017年第1期165-166,共2页
China Continuing Medical Education
关键词
盐酸托烷司琼
地塞米松
化疗
乳腺癌
不良反应
ondansetron hydrochloride
dexamethasone
chemotherapy
breast cancer
adverse reaction
