摘要
艰难梭菌(C.difficile)是一种重要的院内感染病原体,是抗菌药物相关性腹泻的主要致病菌。C.difficile产毒菌株主要通过释放肠毒素A(Tcd A)和细胞毒素B(Tcd B)引起结肠损伤和炎症发生。研究发现C.difficile相关性疾病(CDAD)的严重程度与宿主体内细菌毒素水平相关。然而,不同菌株产毒能力差异较大,与毒素产生过程中涉及的基因调控密切相关。本文就C.difficile毒素致病基因调控机制和抗毒素治疗作一综述。
Abstract Clostridium diffwile （C. difficile） is a major nosocomial infection pathogen and the principal causative agent of antibiotic-associated diarrhea. The toxigenic C. difficile strains cause colonic injury and inflammation mainly by secreting enterotoxin A （TcdA） and cytotoxin B （TcdB）. The severity of C. difficile associated disease （CDAD） is correlated to the toxin level during host infection. However, the toxigenic capacity of C. difficile varies widely among strains, which correlates with the gene regulation involved during toxin production. This article reviewed the regulatory mechanism of C. difficile toxin-associated pathogenic gene and anti-toxin treatment.
作者
林倩云
费稼希
陈烨
LIN Qianyun FEI Jiaxi CHEN Ye(Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Gastroenterology, Guangzhou （510515)
出处
《胃肠病学》
2017年第1期47-50,共4页
Chinese Journal of Gastroenterology
关键词
难辨梭菌
细菌毒素类
基因调控
治疗
Clostridium difficile
Bacterial Toxins
Gene Regulation
Therapy
