摘要
目的:评价降钙素原(简称PTC)在指导抗生素使用时间上的有效性,为临床合理应用抗生素提供参考依据。方法:随机抽取2013年1月-2016年1月在本院ICU住院的患有脓毒血症的患者共120例作为研究对象,根据是否使用PCT指导抗生素使用情况分为试验组(PCT指导)65例、对照组(常规指导)55例,使用生存分析法对两组抗生素使用时间、ICU住院时间、疾病缓解时间进行分析。结果:试验组抗生素使用时间、ICU住院时间及病情缓解时间均低于对照组,两组比较差异均有统计学意义(P<0.05);生存分析亦显示了相同的结果,Log-rank卡方检验P<0.05。两组患者28 d死亡率比较差异无统计学意义(P>0.05)。结论:PCT指导抗生素策略能够缩短脓毒症患者的抗生素使用时间、ICU住院时间及病情缓解时间对死亡率无显著影响,值得临床推广。
Objective： To evaluate the validity of calcitonin original （ PTC ） in the guidance on antibiotic use time, to provide a reference basis for reasonable application of antibiotics.Method： 120 patients with sepsis in ICU were selected as the research objects from January 2013 to January 2013. They were divided into the experimental group （ PCT guide ） of 65 cases and control group （ conventional ） of 55 cases according to whether used PCT as the guidance in antibiotics usage, the antibiotics use time, ICU stay time and disease relief time of two groups were analyzed with survival analysis method.Result： The antibiotic use time, ICU stay time and remission time in experimental group were lower than those of control group, the differences were statistically significant （ P〈O.05 ） .Survival analysis also showed the same result, the Log-rank chi-square test P〈O.OS.Two groups of 28-days mortality were no statistically significant difference （P〈0.05） .Conclusion： Antibiotics PCT guidance strategy can reduce the antibiotic use time, ICU stay time and remission time, it has no significant effect on mortality, worth to clinical promotion.
出处
《中国医学创新》
CAS
2017年第4期22-25,共4页
Medical Innovation of China
基金
伊犁哈萨克自治州科技计划项目(YZ201401029)
关键词
脓毒症
降钙素原
抗生素使用时间
生存分析
Sepsis
Calcitonin original
Antibiotic use time
Survival analysis
