摘要
旨在观察氟哌噻吨美利曲辛联合小剂量阿米替林治疗伴焦虑抑郁障碍的慢性每日头痛患者的疗效。收集重庆市中医院脑病科门诊65例符合纳入标准的患者,并随机分组,对照组采用小剂量阿米替林(25 mg/晚)预防头痛,实验组加用氟哌噻吨美利曲辛片(早中各1片)治疗,疗程3月。评估焦虑抑郁改善情况,观察头痛程度及次数改善程度。结果发现:两组患者在治疗1个月及3个月HAMD及HAMA改善例数差异明显(P<0.05),实验组较对照组评分改善例数明显增多;治疗1个月两组头痛发作程度及次数改善例数差别无统计学意义(P>0.05),治疗3个月实验组头痛发作程度及次数改善例数较对照组明显增多(P<0.05)。由此可见:对伴有焦虑抑郁障碍的慢性每日头痛患者,小剂量阿米替林联合氟哌噻吨美利曲辛治疗对改善焦虑抑郁评分及头痛发作程度和次数是有效的。
To observe the efficacy of flupentixol-melitracen combined with small dose amitriptyline in treating of chronic daily headache（CDH） with anxiety and depression.65 CDH patients accorded with the inclusive criteria were randomly divided into two groups.The control group was treated onlyby amitriptyline with small dose to prevent the headache,while the experimental group was treated additionally by flupentixol and melitracen tablets for three months.The situation of anxiety and depression,and the degree and frequency of headache were assessed.The situation of anxietydepression assessed by HAMD and HAMA showed that there are statistically significant differences between the two groups after one-month and three-month treatment（P 〈0.05）,and that the improvement in experimental group was more significant than the control group.The degree and frequency of headache in the two groups showed no statistically significant difference after one-month treatment（P 〈0.05）.However,the degree and frequency of headache in the experimental group were more significant compared with the control group after three-month treatments（P 〈0.05）.The combination of flupentixol-melitracen and small dose amitriptyline is effective in improving the situation of anxiety and depression,as well as the degree and requency of headache for CDH patients with anxiety and depression.
作者
蓝晓芳
唐军
陈倩
李陈渝
LAN Xiao-fang TANG Jun CHEN Qian LI Chen-yu(Department of Encephalopathy, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China)
出处
《重庆理工大学学报（自然科学）》
CAS
2017年第1期75-78,133,共5页
Journal of Chongqing University of Technology：Natural Science
