摘要
目的探讨急性脑梗死(Acute Cerebral Infarction,ACI)患者血清骨保护素(Osteoprotegerin,OPG)与高敏C反应蛋白水平(High-Sensitivity C-Reactive Protein,hs CRP)的关系。方法测定62例ACI患者(ACI组)和62例健康体检者(正常对照组)血清OPG和hs CRP含量,并收集两组研究对象的临床资料及相关检查结果,比较两组差异。结果 ACI组血清OPG和hs CRP水平均明显高于正常对照组(P<0.05);直线相关分析显示血清OPG与hs CRP水平呈显著正相关(P<0.05);多元逐步回归分析显示血清OPG水平与年龄、体质指数、血糖、收缩压、舒张压、hs CRP呈明显正相关(P<0.05)。结论 ACI患者血清OPG和hs CRP水平均明显升高,血清OPG可能为ACI患者发病的重要炎症生物标志物。
Objective To investigate the relationship between serum osteoprotegerin （OPG） and high-sensitivity C-Reactive protein levels in patients with cerebral infarction. Methods The contents of serum OPG and hsCRP in 62 patients with acute cerebral infaretion （acute cerebral infarction group） and 62 healthy persons （normal control group） were measured, the clinical data of the two groups were collected, and the related results were compared between the two groups. Results The serum OPG and hsCRP levels in patients with acute cerebral infarction group were significantly higher than in normal control group（P 〈 0.05）. The correlation analysis showed that serum OPG and hsCRP levels were significantly positive correlated （P〈 0.05）. Multiple stepwise regression analysis showed that serum OPG levels was positively correlated with age, body mass index, blood glucose, systolic blood pressure, diastolic blood pressure and hsCRP （P 〈 0.05）. Conclusion The serum levels of OPG and hsCRP are significantly increased in patients with acute cerebral infarction. Serum OPG may be an important marker of inflammation in patients with acute cerebral infarction.
作者
陈艳秋
杨礼环
蒋玉琼
刘颖
CHEN Yan-qiu YANG Li-huan JIANG Yu-qiong et al.(Department of Neurology, The People＇s Hospital of Yubei District of Chongqing City, Chongqing, 401120, China)
出处
《黑龙江医学》
2017年第1期15-17,共3页
Heilongjiang Medical Journal
关键词
急性脑梗死
骨保护素
超敏C反应蛋白
Acute cerebral infarction
Osteoprotegerin
High-sensitivity c-reactive protein
