摘要
目的:探讨替格瑞洛对急性ST段抬高型心肌梗死(STEMI)患者的临床疗效及近期预后的影响。方法:入选接受急诊经皮冠状动脉介入术(PCI)治疗的STEMI患者180例,随机分为氯吡格雷组(90例)和替格瑞洛组(90例)。比较两组临床治疗效果;观察两组患者血小板功能变化、主要不良心血管事件(MACE)、不良反应及出血事件发生情况。结果:替格瑞洛组总有效率显著高于氯吡格雷组(93.4%比87.8%,P=0.036);术后24h、术后7d,与氯吡格雷组比较,替格瑞洛组患者血小板聚集率[24h:(62.1±5.2)%比(56.5±5.4)%,7d:(47.3±6.1)%比(38.7±5.2)%]和P2Y12反应单位[24h:(218.1±12.3)U比(201.3±11.1)U,7d:(173.4±11.8)U比(152.6±12.6)U]均显著降低(P均<0.05);两组MACE、不良反应及出血事件发生率差异均无统计学意义(P均>0.05)。结论:替格瑞洛较氯吡格雷能更好地降低血小板聚集率,提高临床疗效,而不增加不良反应及出血事件的发生率。
Objective： To explore therapeutic effect of ticagrelor on patients with acute ST elevation myocardial infarction （STEMI） and its influence on short-term prognosis. Methods： A total of 180 STEMI patients undergoing emergency percutaneous coronary intervention （PCI） were selected, randomly divided into clopidogrel group （n = 90） and tieagrelor group （n = 90）. Clinical therapeutic effect was compared between two groups; platelet function, incidence of major adverse cardiovascular events （MACE）, adverse reactions and bleeding events were observed in two groups. Results： Total effective rate of ticagrelor group was significantly higher than that of clopidogrel group （93.4% vs. 87.8%, P = 0. 036） ; compared with clopidogrel group on 24h and 7d after operation, there were significant reductions in platelet aggregation rate [24h： （62.1 ± 5.2）% vs. （56.5 ± 5.4）%, 7d： （47.3 ±6.1）% vs. （38.7±5.2）%] andP2Y12 reaction unit [24h： （218.1±12.3） Uvs. （201.3±11.1） U, 7d： （173.4±11.8） U vs. （152.6 ± 12.6） U] in ticagrelor, P〈 0.05 all; there were no significant difference in incidence rates of MACE, adverse reactions and bleeding events between two groups, P〉0, 05 all. Conclusion： Compared with clopidogrel, ticagrelor can better reduce platelet aggregation rate and improve clinical therapeutic effect without increasing incidence of adverse reactions and bleeding events.
作者
胡佳勇
余皓月
陈照俊
唐小峰
HU Jia-yong YU Hao-yue CHEN Zhao-jun TANG Xiao-feng(Department of Cardiology, Institute of Field Surgery, Daping Hospital of Third Military Medical University, Chongqing, 400042, Chin)
出处
《心血管康复医学杂志》
CAS
2017年第1期74-77,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
心肌梗死
抗血小板聚集抑制剂
预后
替格瑞洛
Myocardial infarction
Platelet aggregation inhibitors
Prognosis
Ticagrelor
