摘要
质子泵抑制药(PPIs)为H^+/K^+-ATP酶抑制药,可高效快速抑制胃酸分泌,持续时间长久,是新型抑酸药物。也是目前治疗酸相关疾病如胃食管反流病、消化性溃疡及非甾体类抗炎药引起的相关胃肠病变的首选药物。对基础胃酸、夜间胃酸的分泌,胃泌素和食物刺激后的引起的胃酸分泌均有显著的抑制作用。本文就国内已上市的5种PPIs的药动学特征进行综述。
Proton pump inhibitors are H＋/K＋-ATPase inhibitors, which can efficiently inhibit gastric acid secretion for a long time. As the latest inhibitory gastric acid drugs, proton pump inhibitors are the best choices for acid-related diseases such as gastroe- sophageal reflux disease, peptic ulcer and gastrointestinal lesions caused by nonsteroidal anti-inflammatory drugs. Proton pump inhibi- tors have significant inhibition to basal gastric acid, night gastric acid and gastric acid secretion caused by gastrin and food stimulation. This article reviewed the pharmacokinetic characteristics of five proton pump inhibitors in domestic market.
作者
柴蓉蓉
孟鸽飞
丁佳宁
朱全刚
Chai Rongrong Meng Gefei Ding Jianing Zhu Quangang(Pharmaceutical Research Laboratory, Yueyang Integrated Chinese and Western Medicine Hospital Affiliated to Shanghai University of TCM, Shanghai 200437, China Pharmacy Department, Shang- hai Dermatology Hospital)
出处
《中国药师》
CAS
2017年第2期331-333,共3页
China Pharmacist
基金
上海市卫计委中药新药及院内制剂研发项目(编号:2014XP006A)
上海中医药大学第三期杏林学者和优秀学科团队培养计划项目
关键词
质子泵抑制药
药动学
基因多态性
Proton pump inhibitors
Pharmacokinetics
Gene polymorphism
