摘要
目的分析伴心房颤动的风心病患者外周血血管紧张素Ⅱ(AngⅡ)、C反应蛋白(CRP)和白细胞介素6(IL-6)水平,探索肾素-血管紧张素-醛固酮系统(RAAS)活性和炎性反应在瓣膜性房颤发病机制中的作用。方法入选风心病单纯二尖瓣狭窄伴房颤患者38例为试验组,风心病单纯二尖瓣狭窄伴窦性心律患者31例为对照组,所有患者术前心脏彩超检查,并检测外周血AngⅡ、CRP和IL-6水平。结果试验组AngⅡ、CRP和IL-6水平较对照组显著升高,差异有统计学意义(P<0.05);试验组左房径(LAD)和左室射血分数(LVEF)与对照组相比,差异有统计学意义(P<0.05)。结论 RAAS活性增强及炎症反应可能在风湿性二尖瓣狭窄所致房颤的发病机制中起重要作用。
Objective To analyse the level of angiotensin Ⅱ （Ang Ⅱ ）, C-reactive protein（CRP） and interleukin-6 （IL-6） inperipheral blood in rheumatic heart disease patients withatrial fibrillation and explore the effect of renin-angiotensin-aldosterone system（RAAS） activityand inflammatory response in the pathogenesis of valvular diseasecombined with atrial fibrillation. Methods 38 patients with rheumatic simple mitral stenosis and atrial fibrillation were enrolled in this study as theexperimental group and 31 patients with rheumatic simple mitral stenosis and sinus rhythm were enrolled as the control group. All patients underwent preop- erative cardiac uhrasonography, and the levels of Ang Ⅱ, CRP and IL-6 in peripheral blood were measured. Results The levels of Ang Ⅱ, CRP and IL-6 in the experimental group were significantly higher than those in the control group （ P 〈 0. 05 ）. There was significant difference between two groups in left ventricular diameter （LAED） and left ventricular ejection fraction （LVEF） （ P 〈 0. 05 ）. Conclusion RAAS activity and inflammatory response may play an important role in the pathogenesis of atrial fibrillation caused by rheumatic mitral stenosis.
作者
解少强
吴远林
肖祥彬
Xie Shaoqiang Wu Yuanlin Xiao Xiangbin.(The Second People＇s Hospital of Yibin, Yibin , Sichuan 644000, Chin)
出处
《四川医学》
CAS
2017年第1期58-60,共3页
Sichuan Medical Journal
