摘要
应用有限元软件COMSOL建立关节软骨固液双相模型和细胞微观模型,跨尺度研究在生理载荷作用下不同弹性模量的人工软骨修复缺损时,宿主软骨各层细胞的力学环境和液相流场。模拟结果表明,均一弹性模量的人工软骨对不同层区细胞微环境的影响规律不同。随着人工软骨弹性模量增大,浅表层、中间层细胞应力增大,深层细胞应力减小。人工软骨植入改变了中间层、底层软骨的流场方向和营养供给方式,可能会造成软骨细胞营养供应障碍。上述影响可造成修复结果不确定。通过对跨尺度软骨细胞有限元模型进行仿真分析,可定量地评价宿主软骨各层细胞的力学环境,有助于更准确地评估软骨缺损修复的临床效果。
A solid-liquid two-phase finite element model of articular cartilage and a microscopic finite element model of chondrocytes were established using the finite element software COMSOL in this study. The purpose of the study is to investigate the mechanics environment and the liquid flow field of the host cartilage chondrocytes in each layer by multi-scale method, under physiological load, with the different elastic modulus of artificial cartilage to repair cartilage defect. The simulation results showed that the uniform elastic modulus of artificial cartilage had different influences on the microenvironment of different layer chondrocytes. With the increase of the elastic modulus of artificial cartilage, the stress of the shallow surface layer and the intermediate layer chondrocytes increased and the stress of deep layer chondrocytes decreased. The flow field direction of the middle layer and the bottom layer of cartilage can also be changed by artificial cartilage implantation, as well as the ways of nourishment supply of the middle layer and underlying chondrocytes change. A barrier to underlying chondrocytes nutrition supply may be caused by this, thus resulting in the uncertainty of the repair results. With cross-scale finite element model simulation analysis of chondrocytes, we can quantitatively evaluate the mechanical environment of chondrocytes in each layer of the host cartilage. It is helpful to assess the clinical effect of cartilage defect reparation more accurately.
作者
段航天
刘海英
王炜
张春秋
宋书波
黄云鹏
DUAN Hangtian LIU Haiying WANG Wei ZHANG Chunqiu SONG Shubo HUANG Yunpeng(Tianjin Key Laboratory of the Design and Intelligent Control of the Advanced Mechatronical System, Tianjin University of Technology, Tianfin 300384, P.R. China Department of Mechanics, School of Mechanical Engineering, Tianjin University, Tianjin 300354, P.R.China China Automobile Industry Engineering Co.,Ltd, Tianfin 300113, P.R.China Department of Orthopaedics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P.R.China)
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2017年第1期34-40,47,共8页
Journal of Biomedical Engineering
基金
国家自然科学基金青年基金(11402172)
国家自然科学基金重点资助项目第二合作单位(11432016)
国家自然科学基金(11572222)
天津市自然科学重点基金(15JCZJC32800)
福建省卫生系统中青年人才培养项目(2013-ZQN-ZD-19)
关键词
数值模拟
缺损软骨
软骨细胞
应力
流场
numerical simulation
cartilage defect
chondrocyte
stress
flow field
