摘要
目的探讨免疫调节剂核糖核酸Ⅱ用于阿那曲唑治疗乳腺癌所致骨关节症状的临床疗效。方法选择156例绝经后Ⅰ~Ⅲ期女性乳腺癌经阿那曲唑治疗引发骨关节症状患者,分为核糖核酸Ⅱ组(给予核糖核酸Ⅱ200 mg,静滴,每日1次,治疗4周)和对照组(给予生理盐水),采用FACT-G量表、WOMAC指数评价症状变化程度,采用ELISA方法检测治疗前后外周血清中的细胞因子干扰素γ(IFN-γ)、白细胞介素-4(IL-4)、骨钙素(BGP)、骨碱性磷酸酶(BALP)、Ⅰ型胶原羧基端前肽(CICP)含量。结果与对照组比较,使用核糖核酸Ⅱ治疗后,患者的骨关节病变、疼痛程度和生活质量均明显改善(P<0.05),IL-4水平升高、IFN-γ水平降低(P<0.05),骨代谢指标BALP、CICP含量明显降低(P<0.05)。结论核糖核酸Ⅱ能够改善芳香化酶抑制剂治疗相关的骨关节症状,其机制可能与免疫调节作用有关。
Objective To investigate the effect of immunomodulator ribonucleic acid Ⅱon anastrozole-related joint symptoms. Methods A total of 156 postmenopausal women patients with stage Ⅰ -Ⅲ breast cancer and anastrozole-related joint symp- toms were enrolled. These patients were divided into two groups： One group were treated by ribonucleic acid Ⅱ （200 mg, intravenous infusion, Ⅰ time a day）as the experimental group, the other was treated by saline as the control group. The degree of symptom change was evaluated by FACT-G and WOMAC. The levels of serum cytokines（ IFN-γ and IL-4） , the bone gla protein（BGP） , bone alkaline phosphatase （BALP） and Ⅰ collagen carhoxyl-terminal propeptide（ CICP ） of bone metabolism were detected by ELISA method. Results In comparison with the control group, ribonucleic acid Ⅱ significantly reduced the severity of musculoskeletal symptoms and pain, and also improved the quality of life（P〈0. 05）. In ribonucleic acid lI group, the blood level of IL-4 was increased, whereas IFN-γ was decreased （P〈0.05）. as well as, the indexes of bone metabolism BALP and CICP were significantly lower than those in the control group（P〈0. 05）. Conclusion Ribonucleic acid Ⅱ could improve aromatase inhibitor related musculoskeletal symptoms by the role of immunity adjustment.
作者
马文杰
张仲柏
高堃
王静萱
张清媛
MA Wenjie ZHANG Zhongbai GAO Kun WANG Jingxuan ZHANG Qingyuan(The Third Department of Medicine, Cancer Hospital Affiliated to Harbin Medical University, Harbin 150086, China)
出处
《临床肿瘤学杂志》
CAS
2017年第1期26-30,共5页
Chinese Clinical Oncology
基金
国家高技术研究发展计划(863计划)资助项目(2014AA022206)
国家自然科学基金面上资助项目(81472490)
