摘要
目的:观察左乙拉西坦与维生素B6联用对其药物不良反应的影响。方法:回顾性分析2010年1月-2015年6月就诊于神经内科癫痫专科并随访大于24周的患者110例。根据自愿原则将110例门诊患者随机分为研究组(左乙拉西坦+维生素B6)和对照组(单用左乙拉西坦),在治疗后的4、12、24周动态随访其疗效和不良反应。结果:治疗24周后,研究组行为的不良反应包括兴奋、攻击、烦躁、激惹等副作用的出现明显低于对照组(P<0.05)。结论:联用维生素B6对左乙拉西坦药物不良反应的影响有一定的改善。
Objective： To observe the effects of Levetiracetam combined with Vitamin B6 on the adverse drug reactions. Methods： A total of 110 cases of patients with epilepsy who received more than 24-week from the Epilepsy clinic of the Leshan Hospital between Jan. 2010 and Jun. 2015 were retrospectively analyzed. The 110 patients were randomly divided into the study group （Levetiracetam ＋ Vitamin B6） and the control group （Levetiracetam only） according to the voluntary principles, and dynamic follow-ups of the curative effects and adverse reactions were conducted in the 4th, 12th, and 24th week after the treatment. Results： The incidence of adverse reactions （including excitement, aggressive behavior, irritability, and other side effects） in the study group was significantly lower than that in the control group after 24-week treatment （P 〈 0.05）. Conclusion： The treatment combining with Vitamin B6 could relieve the adverse drug reactions caused by Levetiracetam to a certain degree.
作者
胡佳
黄惠英
Hu Jia Huang Huiying(Leshan People＇s Hospital, Leshan 614000, China)
出处
《中国药事》
CAS
2017年第1期112-115,共4页
Chinese Pharmaceutical Affairs
