摘要
目的探讨玉屏风颗粒联合依巴斯汀治疗过敏性鼻炎患者的临床疗效。方法过敏性鼻炎患者100例随机分为研究组与对照组，每组患者50例。研究组采用玉屏风颗粒联合依巴斯汀治疗，对照组仅采用依巴斯汀治疗。两组均以2周为治疗疗程。对比分析两组患者治疗总有效率，治疗前与治疗2周鼻塞、鼻痒、喷嚏积分及炎症因子IL-4、IL-10、IL-12水平变化，药物不良反应发生情况。结果两组治疗总有效率对比差异有统计学意义（P〈0．05）。治疗后，两组鼻塞、鼻痒、喷嚏积分较治疗前下降，差异有统计学意义（P〈0．05）；治疗后，研究组鼻塞、鼻痒、喷嚏积分低于对照组，差异有统计学意义（P〈0．05）。治疗后，两组IL-4、IL-10较治疗前下降，而IL-12较治疗前增加，差异有统计学意义（P〈0．05）；治疗后，研究组IL4、IL-10低于对照组，而IL-12高于对照组，差异有统计学意义（P〈0．05）。两组用药2周期间均未出现明显药物不良反应。结论玉屏风颗粒联合依巴斯汀治疗过敏性鼻炎患者临床疗效显著，可降低炎症因子IL-4、IL—10水平，增加IL-12水平，且用药安全性良好。
Objective To investigate the effect of Yupingfeng particles combined with ebastine in the treatment of patients with allergic rhinitis. Methods 100 cases of allergic rhinitis were randomly divided into study group and control group, 50 cases in each group. Study group was treated with Yupingfeng granules combined with ebastine, while control group was treated with ebastine only. The two groups were treated for 2 weeks. The total effective rote, the scores of nasal congestion, nasal itching, sneezing, the levels of inflammatory factors （IL-4, IL- 10, IL-12） before and 2 weeks alter treatment, and the occurrence of adverse drug reactions of the two groups were compared and analyzed. Results There was statistically significant difference in the total effective rate of treatment between the two groups （P〈0.05）. After treatment, the scores of nasal congestion, nasal itching, sneezing in two groups significantly decreased （P〈0.05）; the scores of nasal congestion, nasal itching, sneezing in study group were lower than those in control group （P〈0.05）. After treatment, the levels of IL-10, IL-4 in two groups decreased, while the level of IL- 12 increased （P〈0.05）; the levels of IL-10, IL-4 in study group were lower than those in control group, while the level of IL-12 was higher than that in control group （P〈0.05）. There were no significant adverse drug reactions during 2 weeks of treatment in the two groups. Conclusion Yupingfeng particles combined with ebastine in the treatment of patients with allergic rhinitis has obvious clinical curative effect, which can reduce the levels of inflammatory cytokines IL-4 and IL-10 and increase the level of IL-12, with good medication safety.
出处
《国际医药卫生导报》
2017年第4期533-535,共3页
International Medicine and Health Guidance News
关键词
玉屏风颗粒
依巴斯汀
过敏性鼻炎
疗效
炎症因子
Yupingfeng particle
Ebastine
Allergic rhinitis
Curative effect
Inflammatory factor
