摘要
背景:3D生物打印利用组织工程及干细胞研究的成果,以活细胞及其他细胞活性成分作为打印原料,最终实现生物活性组织的打印和制作。目的:对3D打印技术目前在整形外科的应用及研究进展作一综述。方法:由第一作者检索从2007至2016年PubM ed、Ovid、中国知网等数据库收录的关于3D打印技术在整形外科应用及研究进展的文献。英文检索词为"three-dimensional printing,3D printing,plastic and reconstructive surgery,orthopaedic,organ printing",中文检索词为"3D打印,整形外科,修复重建,器官打印",按纳入、排除标准筛选最终纳入44篇文献进行分析、总结。结果与结论:3D打印目前在颅颌面骨重建、耳鼻再造、皮肤打印及乳房重建等方面的应用较为广泛,特别在制作骨替代品及个性化假肢、假体方面技术已相当成熟。3D打印技术经历了从假体制作到生物活性打印的发展过程,最终有望进入器官打印阶段,彻底解决自体或同种异体移植所存在的局限。
BACKGROUND： Three-dimensional（3D） biological printing uses tissue engineering and stem cell research results, and takes living cells and other cell active ingredients as printing materials, finally realizing biological tissue printing and production.OBJECTIVE： To review the application and research progress of 3D printing in the field of orthopaedics. METHODS： A computer-based search of Pub Med, Ovid, and CNKI databases was performed for relevant literatures about application and research progress of 3D printing in the field of orthopaedics, all of which were published from 2007 to 2016. ＂three-dimensional printing, 3D printing, plastic and reconstructive surgery, orthopaedic, organ printing＂ were used as keywords during the searching process. According to inclusion and exclusion criteria, 44 articles were included for further analysis and summary. RESULTS AND CONCLUSION： 3D printing was mainly applied into craniomaxillofacial reconstruction, nose, ear and cartilage reconstruction, breast reconstruction, and skin printing. Its application in bone and prosthetic fabrication was quite mature. Based on the development of 3D printing from prosthetic fabrication to bioactiveprinting, organ printing will eventually become reality to completely solve the autologous or allograft transplantation limitations.
出处
《中国组织工程研究》
CAS
北大核心
2017年第3期428-432,共5页
Chinese Journal of Tissue Engineering Research
