摘要
目的:调查本社区65岁以上老年人高尿酸血症(HUA)的患病情况,并对其相关危险因素进行分析。方法:选择2015年4—10月在本社区进行体检的2 433例65岁以上老年人,进行问卷调查、体格检查及实验室检查。根据血尿酸水平分为HUA组290例和正常尿酸组2 143例,采用非条件Logistics回归分析HUA的影响因素。结果 :2 433例受检者中,HUA患病率为11.92%,男性和女性患病率分别为18.58%和6.77%(P=0.000),HUA组男性比例、平均年龄、高血压患者比例、BMI、血肌酐、尿素、γ-谷氨酰转肽酶、总蛋白、白蛋白、TG水平均较正常尿酸组升高,而HDL水平较正常尿酸组明显下降(P<0.05),多因素Logistics回归分析显示超重、肾功能下降、γ-谷氨酰转肽酶升高、白蛋白升高、高TG血症为HUA的危险因素(P<0.05)。结论 :该社区65岁以上老年人HUA患病率相对不高,超重、肾功能下降、高TG血症可能是发生HUA的危险因素,应采取相应措施进行预防。
Objective： To investigate the prevalence of hyperuricemia（HUA）among the community residents over 65 years old in this community and analyze the related risk factors. Methods： A total of 2 433 elderly people over 65 years old were selected from April to Oct. 2015 who had the health check in this community and investigated with the questionnaire and had the health examination and biochemical tests. According to the levels of HUA, they were divided into a HUA group and a normal uric acid group. The non conditional logistic regression analysis was used to analyze the influencing factors of HUA. Results： Of 2 433 examined subjects, the total incidence of HUA was 11.92%, and the prevalence of male and female was 18.58% and 6.77%, respectively（P=0.000）. The male ratio, the average age, the proportion of patients with hypertension, BMI, serum creatinine, urea, γ-alanine aminotransferase（γGT）, total protein, albumin, and triglyceride（TG）levels in the HUA group were higher than those in the normal uric acid group, but high-density lipoprotein（HDL）level was significantly lower in the HUA group than that in the normal uric acid group（P〈0.05）. Multi factor Logistics regression analysis showed that overweight, renal function decline, γGT, elevated albumin, and high TG were the risk factors of HUA（P〈0.05）. Conclusion： The prevalence rate of HUA is relatively low in the elderly people over 65 years old in this community. The overweight, kidney function decline and high TG levels may be the risk factors of HUA, and corresponding measures should be taken for prevention.
作者
阮玉凤
RUAN Yufeng(Weifang Community Health Service Center of Pudong New District, Shanghai 200122, China.)
出处
《上海医药》
CAS
2017年第2期35-37,40,共4页
Shanghai Medical & Pharmaceutical Journal
