摘要
目的探讨在儿童1型糖尿病合并糖尿病酮症酸中毒（DKA）临床治疗中，胰岛素泵的应用效果。方法选取我院儿科2010年3月～2016年3月收治的儿童1型糖尿病酮症酸中毒患儿48例，并随机将其分为对照组（24例）与治疗组（24例）。均给予两组患儿常规基础治疗。在此基础上，给予对照组小剂量胰岛素行静脉滴注；给予治疗组患儿行胰岛素泵的给药方式进行治疗。结果在治疗后，与对照组相比，治疗组低血糖发生次数明显较少，平均每天血糖明显较低，住院时间明显较短，差异具有统计学意义（P〈0．05）。两组患儿血糖值均有所下降，但在达到目标血糖值时间方面的差异不明显（P〉0．05）。而在尿酮体恢复时间与血酮体恢复时间方面，与对照组相比，治疗组的好转时间明显较短，且低血糖发生率明显偏低（P〈0．05）。结论胰岛素泵在治疗童1型糖尿病合并酮症酸中毒过程中具有良好的治疗效果，且安全性较高，但并不适用于重症糖尿病酮症酸中毒患儿。
Objective To explore the application effect of insulin pump in children with type 1 diabetes mellitus and diabetic ketoacidosis （DKA） in the clinical treatment. Methods 48 cases of children with type 1 diabetic ketoacidosis cured in our hospital from March 2010 to March 2016 were selected and randomly divided into control group （24 cases） and treatment group （24 eases）. All patients were given conventional basic treatment.On this basis, the control group was given a small dose of insulin infusion, and the treatment group was treated with insulin pump therapy. Results After treatment, compared with the control group, the incidence of hypoglycemia in the treatment group was significantly less, the average daily blood glucose was significantly lower, the length of hospital stay was significantly shorter, and the difference was statistically significant （P 〈 0.05）. Blood glucose levels in the two groups were decreased, but the difference was not significant （P 〉 0.05）. In the urine ketone recovery time and recovery time of blood ketone body, compared with the control group, the treatment group improved significantly shorter, and the incidence of hypoglycemia was significantly lower （P 〈 0.05）. Conclusion The insulin pump has good therapeutic effect in the treatment of children with type 1 diabetes mellitus ketoacidosis process, and it has higher security, but it does not apply to children with severe diabetic ketoacidosis.
出处
《中国医药科学》
2016年第20期70-72,共3页
China Medicine And Pharmacy
关键词
胰岛素泵
酮症酸中毒
治疗
1型糖尿病
Insulin pump
Ketoacidosis
Treatment
Type 1 diabetes mellitus
