摘要
目的探讨左乙拉西坦(LEV)联合丙戊酸治疗对癫痫患者脑电图的改变以及临床效果。方法收集在科室就诊的癫痫持续状态患者80例作为研究对象,随机分为观察组(42例)和对照组(38例),在常规基础治疗的基础上,对照组行丙戊酸钠注射治疗,首剂10 mg/kg,5 min内静脉注射;而后以0.5~1 mg/(kg·h)持续静脉滴注;观察组在行丙戊酸钠注射的同时,口服LEV片。治疗后24 h,分析两组的治疗效果和脑电图异常改变,比较两组的不良反应及复发情况。结果观察组有效率为85.71%,对照组为65.79%,两组比较有统计学差异(P<0.05);治疗前观察组有33例存在脑电图异常,治疗后25例得到明显改善,改善率为75.8%;对照组改善率为42.9%,两组改善率比较有统计学差异(P<0.05)。治疗期间,观察组复发率明显低于对照组(P<0.05),不良反应情况无统计学差异(P>0.05)。结论 LEV联合丙戊酸治疗对癫痫患者脑电图的改善以及临床疗效显著,建议临床推广应用。
Objective To explore the EEG Changes Caused by and clinical effects of levetiracetam （LEV） combined with valproic acid in patients with epilepsy. Methods A total of 80 patients with epilepsy to receive treatment in our department were selected as research subjects and were randomly divided into an observation group（n=42） and a control group （n=38）. Based on the conventional treatment, the control group received valproate sodium injection. The first dose was 10 mg/kg, intravenously injected within five minutes, followed by 0.5-1 mg/（kg·h） continuously injected. The observation group also received valproate sodium injection, while taking LEV orally. After 24 hours since the treatment, the curative effects, changes caused to EEG, and adverse reactions and recurrence were analyzed and compared between the two groups. Results The effective rate in the observation group was 85.71% and that in the control group was 65.79%, which showed a significant difference between the two groups（P 〈 0.05）. In the observation group, there were 33 patients whose EEG showed abnormality before treatment, and 25 ones among them were improved significantly, with an improvement rate of 75.8% ; the improvement rate in the control group was 42.9% , which showed a significant difference between the two groups （P 〈 0.05）. During the treatment, the recurrence rate in the observation group was significantly lower than that in the control group （P 〈 0.05）, and there was no significant difference in adverse reactions between the two groups （P 〉 0.05）. Conclusion LEV combined with valproic acid in the treatment of patients with epilepsy can improve the EEG and has significant clinical effects, so it is worthy of clinical promotion and application.
出处
《西南国防医药》
CAS
2017年第2期149-151,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
癫痫
LEV
丙戊酸
脑电图
疗效
epilepsy
LEV
valproic acid
electroencephalogram
curative effect
