摘要
目的探讨固肾安胎方联合低分子肝素钙对原因不明复发性流产患者性激素及外周血免疫细胞的影响。方法将106例原因不明复发性流产患者随机分为2组,西药组52例妊娠后给予传统西医安胎治疗(小剂量阿司匹林肠溶片+黄体酮注射液+芬吗通)至孕12周,同时给予低分子肝素钙治疗至孕16周;中西医结合组54例于发现优势卵泡排出并同房日起开始口服固肾安胎中药,妊娠后继续服用至妊娠16周,其余西医治疗同西药组。观察2组孕8周和孕10周血清β-HCG、P、E2水平和N、Plt值和2组治疗前及治疗3周后淋巴细胞亚群比例,统计2组出现阴道出血、流产情况及治疗成功情况。结果孕8周和10周时,中西医结合组β-HCG、E2水平均明显高于西药组(P均<0.05),N、Plt均明显低于西药组(P均<0.05);治疗3周后,2组T细胞比例明显升高(P均<0.05),NK细胞比例明显降低(P均<0.05),且中西医结合组改善情况明显优于西药组(P均<0.05);中西医结合组阴道出血发生率明显低于西药组(P<0.05);2组流产率和治疗成功率比较差异均无统计学意义(P均>0.05),但中西医结合组流产者流产孕周明显高于西药组(P<0.05)。结论固肾安胎方联合低分子肝素钙治疗原因不明复发性流产,能提高治疗成功率和流产孕周,这可能与固肾安胎方联合低分子肝素钙能显著降低母体血液N、Plt水平,调节外周血淋巴细胞亚群比例有关。
Objective It is to observe the effect of combination treatment with Chinese and western medicine on sex hormone and peripheral immune cells in patients with unexplained recurrent miscarriage. Methods One hundred and two patients with unexplained recurrent miscarriage were randomly divided into two groups, the western medicine group （n - =52） were treated with traditional western medicine therapy （low-dose aspirin enteric-coated metformin hydrochloride ＋ progestin injection ＋ Estradiol and Dydrogesterone tablets） for 12 weeks and with heparin calcium for 16 weeks after pregnancy, the combination group （n = 54） was treated with Gushen Antai Chinese medicine after ovulation and intercourse, the treatment was not stopped until pregnancy for 16 weeks, the western medicine therapy was the same as western medicine group. The levels of serum B- HCG, P , E2 and the value of N and Pit, proportion of lymphocyte subsets were detected after pregnancy for 8 and 10 weeks in both groups, vaginal bleeding, abortion and successful treatment were recorded and compared. Results The levels of serum B- HCG, P , E were higher while that of N and Pit were lower in combination group than that in western medicine group when pregnancy for 8 and 10 weeks（ P 〈 0. 05 ） . After treatment for 3 weeks, the proportion of lymphocyte subsets was increased and that of NK cells was decreased in both groups （P 〈0. 05） , and the improvements in combination group were better than that in western medicine group （ P〈 0. 05 ） . The incidence rate of vaginal bleeding was lower in combination group than that in western medicine group （P 〈 0. 05） , there was no significant difference in abortion and successful treatment between the two groups （P 〉0.05） , but the pregnancy time in the patients with abortion in combination group was longer than that in western medicine group （ P〈 0. 05 ） . Conclusion Gushen Antai
出处
《现代中西医结合杂志》
CAS
2017年第5期461-463,480,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
湖北省妇幼保健院科研课题(220933013)
关键词
固肾安胎方
复发性流产
低分子肝素钙
外周血免疫细胞
Gushen Antai decoction recurrent abortion low molecular heparin calcium peripheral immune cells
