摘要
血管生成是肿瘤组织迅速增殖和转移、扩散的重要条件之一,血管内皮生长因子是肿瘤血管生成的关键调控者,也是一种表达于整个肿瘤生命周期的血管生成因子。针对血管生成、特别是血管内皮生长因子为靶点来进行肿瘤治疗已经成为当前研究的一个热点。天然产物及其化学成分具有良好的抑制肿瘤血管生成的效用,且毒副作用小,具有多成分、多环节、多靶点效应等特点,该文以三叶青为代表,综述了天然产物在以血管内皮生长因子为作用靶点的抑制肿瘤转移方面的研究进展。
Angiogenesis is very important for the proliferation, diffusionand metastasisof tumor. Vascular endothelial growth factor （VEGF） is the key regulator of tumor angiogenesis which is expressed throughout the life cycle of tumor. Inhibition ofangiogenesis related factors, especially for VEGF, has been made a hot topicintumor therapycurrently. Natural products and their chemical compounds have shown activity in inhibition of tumor angiogenesis which have the advantages of no side effects, multi components, multi link, multi targets. In this review, we summarized the progress of natural products, especially for T. hemsleyanum, in inhibition of VEGF-mediated tumor metastasis.
作者
孙磊
李照
高飞
白岩
钱永常
王向军
SUN Lei LI Zhao GAO Fei BAI Yan QIAN Yong-chang WANG Xiang-jun(Institute of Traditional Chinese medicine, School of Forestry and Biotechnology, Zhejiang A＆F University, Hang- zhou 311300, China)
出处
《药物生物技术》
CAS
2016年第6期540-543,共4页
Pharmaceutical Biotechnology
基金
浙江省自然科学基金资助项目(No.LY16H280014)
浙江农林大学科研发展基金资助项目(No.2012FR080)
