摘要
Wnt信号通路是一条保守复杂的信号通路,调节干细胞自我更新、细胞增殖、分化及凋亡,参与胚胎发育、组织稳态及细胞癌变等。Wnt蛋白是一类富含L-半胱氨酸的分泌型糖蛋白,通过影响由结直肠腺瘤性息肉蛋白(APC)、轴蛋白(Axin)、糖原合成酶激酶-3β(GSK-3β)及酪蛋白激酶1(CK1)等组成的降解复合物的磷酸化作用调控胞质内β-catenin的浓度变化,参与Wnt信号通路的激活。经典Wnt/β-catenin通路的异常激活与人类恶性肿瘤密切相关。本文综述了该信号通路相关转录因子及与其他信号通路(Notch通路、TGF-β/BMP通路、Hedgehog通路、Hippo/YAP/TAZ通路)在肿瘤中的相互串话,进一步了解Wnt信号通路与肿瘤关系,为治疗提供潜在靶点。
The Wnt signaling pathway is a conserved and complex pathway that plays an important role in the regulation of stem cell self-renewal, proliferation, differentiation and apoptosis, involved in embryonic development, tissue homeostasis and cell carcinogenesis. Wnt proteins are a kind of secreted glycoprotein rich in L-Cysteine, and they can regulate the concentrations of β-catenin in the cytoplasm and take part in the activation of Wnt signal pathway by influencing the phosphorylation of destruction complex made up of adenomatous polyposis coli （APC）, axial protein （Axin）, glycogen synthase kinase 3 beta （GSK-313）, casein kinase 1 （CK1）, and so on. The abnormal activation of classic WNT/β-catenin signal pathway is closely related to human rrialignant tumors. This paper reviews the cross-talk between the transcription, factors of Wnt signal pathway and other signal pathways （Notch pathway, TGF-β/BMP pathway, Hedgehog pathway, Hippo/YAP/TAZ pathway）, in order to know more about the relationship between Wnt signal pathway and cancer, and provide potential target for the treatment.
出处
《中国医药导报》
CAS
2016年第36期71-73,77,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81360351)
贵州省科学技术基金项目(黔科合J字[2014]2186号)
