摘要
目的:分析广西来宾地区不同年龄段女性乳腺癌患者的临床病理特点。方法:选取2010年1月至2014年12月在广西来宾市人民医院经病理检查确诊的乳腺癌患者276例作为研究对象,按不同年龄段分为青年组(42例)、中年组(166例)、老年组(68例),分析各组患者的临床病理特点,包括临床分期(TNM分期)、病理类型、淋巴结转移情况等。免疫组织化学法检测3组雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体-2(C-erbB-2)、细胞增殖标记物Ki-67及抑癌基因P53的表达阳性率。结果:3组患者病理类型、临床分期的分布比较,差异有统计学意义(P<0.05),且均以浸润性导管癌所占比例最高,临床分期中以Ⅱ期所占比例最高;3组患者淋巴结转移情况比较,差异无统计学意义(P>0.05);3组不同年龄段患者P53、ER、PR的表达情况比较,差异无统计学意义(P>0.05),3组患者P53、ER、PR总体阳性率分别为52.9%、53.3%、41.3%;3组C-erbB-2、Ki-67表达阳性率比较,差异有统计学意义(P<0.05),3组患者C-erbB-2、Ki-67总体阳性率分别为26.4%、69.2%。结论:不同年龄段女性乳腺癌患者的临床病理特点存在差异性,淋巴结是否发生转移与年龄无关,C-erbB-2、Ki-67表达阳性率与年龄有一定的关系。掌握不同年龄段女性乳腺癌的临床病理特点及其关系具有重要的临床意义。
Objective： To analyze the clinical pathological characteristics of female breast cancer patients with different ages in Laibin, Guangxi. Methods： 276 cases of female breast cancer patients in our hospital from January 2010 to December 2014 were selected and divided into young group, middle-age group and old-age group according to their age. The clinical pathological characteristics including the clinical stage, pathological classification and lymph node metastasis status of patients were analyzed. The expression levels of estrogen receptor （ER）, progestogen receptor （PR）, human epidermal growth factor receptor-2 （C- erbB-2）, cell proliferation markers Ki-67 and anti-oncogene P53 were determined by immunohistochemis- try. Results： There were statistical differences in pathological pattern and stage among groups （P 0.05）. The invasive ductal carcinoma was the most prevalent pathological type, and patients were mainly in stage II. There were no significant differences in P53, ER and PR expression as well as lymph node metastasis among groups （ P 〉0. 05）. The total positive rates of PR, ER and P53 expressions in young group, middle-age group and old-age group were respectively 52.9%, 53.3% and 41.3%. The overall positive rates of C-erbB-2 and Ki-67 expressions were 26.4% and 69.2% respectively, and they showed significant differences among groups （ P 〈0.05）. Conclusion： Female breast cancer patients in different ages manifested different clinicopathologic characteristics. Lymph node metastasis had no association with age, and the expression of C-erbB-2 and Ki-67 was correlated with age.
作者
谭景浪
李常明
Tan Jinglang Li Changming(Department of Pathology Department of Cardiothoracic Surgery, The People＇s Hospital of Laibin, Laibin 524000, China)
出处
《广西医科大学学报》
CAS
2017年第2期284-287,共4页
Journal of Guangxi Medical University
关键词
年龄
乳腺癌
病理特点
免疫组化
age
breast cancer
pathological characteristic
immunohistochemistry
