摘要
目的探究活化蛋白C-蛋白C抑制物复合物(APC-PCI)、D-二聚体联合检测对静脉血栓栓塞症(VTE)的诊断价值。方法 81例疑诊VTE的患者,检测血浆D-二聚体及APC-PCI复合物浓度,经过影像学确诊31例VTE。分析两者对VTE的诊断价值。结果 VTE患者血浆APC-PCI复合物浓度显著高于非VTE组。以0.88ng/mL为诊断界值,敏感性为64.5%,特异性为86%,以0.5μg/mL为D-二聚体界值,敏感性为92.3%,特异性为66.7%。两者串联检测,特异性90%,阳性预测值78.3%;并联检测可显著提高敏感性和阴性预测值。结论 APC-PCI复合物浓度在VTE中显著升高,与D-二聚体联合检测后可提升阳性和阴性预测值,有利于高危人群的床旁快速诊断和鉴别。
Objective To explore the diagnostic value of combined detection of APC-PCI and D-dimmer in the diagnosis of venous thromboembolism （VTE）. Methods 81 cases of suspected venous thromboembolism were collected. Their plasma levels of D-dimer and APC-PCI complexes were detected after admission. 31 cases were fi- nally diagnosed as VTE by imageological examination. The diagnostic value of the two groups of VTE was analyzed. Results The plasma concentrations of APC-PCI in VTE patients were significantly higher than those in non VTE group. Taking 0. 88ng/mL as the cut-off value in the diagnosis of VTE, the sensitivity was 64. 5%, and the specifici- ty was 86%. Taking 0. 5 g/mL as the cut-off value of D-dimer, the sensitivity was 92. 3%, and the specificity was 66. 7%. The specificity of the combined detection was 90%, and the positive predictive value was 78.3%. Conclu- sion APC-PCI compound increases significantly in VTE, and the combined detection of APC-PCI complex and D-di- met can improve the positive and negative predictive value, which can conducive to the high risk population of rapid bedside diagnosis and differential diagnosis.
作者
韩锐
李秀
HAN Rui LI Xiu(Pneumology Department, the First People Hospital of Hefei, Hefei, Anhui 230061, China)
出处
《临床肺科杂志》
2017年第3期421-423,共3页
Journal of Clinical Pulmonary Medicine
基金
合肥市科技局自筹基金项目合科【2011】25号-6
