摘要
目的:探讨埃索美拉唑治疗老年胃溃疡的幽门螺杆菌(HP)根除效果及对基质金属蛋白酶(MMP)、金属蛋白酶组织抑制剂-1(TIMP-1)表达的影响。方法:选取2014年6月至2015年6月于我院进行治疗的180例老年胃溃疡患者,随机分为对照组和观察组,各90例。对照组给予奥美拉唑治疗,观察组给予埃索美拉唑治疗。比较两组患者的临床疗效、Hp根除率及不良反应发生率,治疗前后MMP-3、MMP-7、MMP-9和TIMP-1的表达情况。结果:观察组患者的临床治疗总有效率(93.3%)明显高于对照组(72.2%)(P<0.05);观察组患者的HP根除率(87.8%)明显高于对照组(66.7%),差异有统计学意义(P<0.01);观察组患者的不良反应发生率(3.3%)明显低于对照组(14.4%)(P<0.05);治疗后,两组患者的MMP-3、MMP-7、MMP-9和TIMP-1的表达均降低(P<0.05),且观察组较对照组更显著(P<0.05)。结论:埃索美拉唑治疗老年胃溃疡能够显著根除HP,临床疗效显著且安全可靠,此外,还能够有效降低MMP-3、MMP-7、MMP-9和TIMP-1的表达。
Objective： To explore the effect of esomeprazole on helicobacter pylori（ HP） eradication of gastric ulcer in the aged and the expression of matrix metalloproteinase（ MMP）,tissue inhibitor of metalloproteinase-1（ TIMP-1）. Methods： 180 cases of elderly patients with gastric ulcer treated in our hospital between June 2014 and June 2015 were randomly divided into the control group and observation group,90 cases respectively.Omeprazole was applied to the control group,and esomeprazole was applied to the observation group. The clinical efficacy,Hp eradication rate and the incidence of adverse reaction were compared. The extraction of gastric juice was operated before and after the treatment,the expressions of MMP-3,7,9 and TIMP-1 were determined and compared by ELISA. Results： The total effective rate of the observation group（ 93. 3%） was obviously higher than that of the control group（ 72. 2%）,the difference was statistically significant（ P〈0. 05）; the Hp eradication rate of the observation group（ 87. 8%） was obviously higher than that of the control group（ 66. 7%）,the difference was statistically significant（ P〈0. 01）; the incidence of adverse reaction of the observation group（ 3. 3%） was obviously lower than that of the control group（ 14. 4%）,the difference was statistically significant（ P〈0. 05）;After treatment,the expressions of MMP-3,7,9 and TIMP-1 of the two groups were decreased,and the observation group were better（ P〈0. 05）. Conclusion： Esomeprazole in the treatment of elderly patients with gastric ulcer can make excellent eradication of HP,its clinical curative effect is distinct with good drug safety. In addition,the expressions of MMP-3,7,9 and TIMP-1 can be decreased significantly with the application of esomeprazole.
作者
王瑞芳
WANG Rui- fang(The Third People＇s Hospital of Haikou City, Haikou 571100, China)
出处
《现代医学》
2016年第9期1263-1266,共4页
Modern Medical Journal
