摘要
目的:通过对视觉和听觉事件相关电位P300系列成分的研究,了解其临床电生理学特征,从而为临床评价脑认知功能的状态提供依据。方法:使用经典的Odball P300刺激范式对29名志愿者分别进行视觉、听觉刺激,采用64导ERP数据采集分析系统进行数据采集及离线分析。使用SPSS 17.0对所得数据进行统计分析。结果:听觉P1波幅和潜伏期的性别主效应均显著(F=5.44,22.45;P=0.02,0.00),N1波幅的性别和电极部位主效应也均显著(F=4.50,17.85;P=0.04,0.00),P2波幅的电极部位主效应明显(F=17.64,P=0.00);而视觉P1、N1、P2的波幅和潜伏期中,仅P2波幅的电极部位主效应显著(F=3.51,P=0.04)。视觉性P1、N1、P2电位潜伏期明显小于听觉性P1、N1、P2(F=20.45,104.12,107.26;P=0.00),P1和N1的波幅明显低于听觉性P1、N1(F=7.05,133.82;P=0.01,0.00),听觉性N2、P300电位潜伏期明显大于视觉性N2和P300(F=52.43,52.64;P=0.00),视觉N2的波幅也明显高于听觉性N2(F=26.00,P=0.00),但视觉性P300波幅与听觉性P300无差异(F=0.00,P=0.989)。结论:听觉诱发电位具有早期外源性感知电位影响因素较多,P300等晚期内源性认知电位虽然相对稳定,但有波幅较低的缺点;视觉诱发电位早期外源性感知电位同样结果较稳定但波幅低,而晚期内源性认知电位具有波幅高和波形分化好的优点。因此同时检测视觉和听觉P300能够更加准确地评价大脑的认知功能。
Objective：To provide evidence for the clinical evaluation of brain cognitive function by studying the P300 series of visual and auditory event related potentials and their clinical electrophysiological characteristics.Methods：First,using the classic Odball P300 stimulus paradigm to perform visual and auditory stimuli in 29 volunteers.Then,Using 64-channel ERP data acquisition and analysis system to make data acquisition and off-line analysis.Finally,using the SPSS 17.0to make statistical analysis of the data obtained.Results：Auditory P1 amplitudes and latency showed significant main effects of genders（F=5.44,22.45;P〈0.05）;Auditory N1 amplitudes showed significant main effects of genders and electrode sites（F=4.50,17.85;P〈0.05）;Auditory P2 amplitudes showed significant main effects of electrode sites（F=17.64,P〈0.05）.But,in visual P1,N1,P2 amplitudes and latency,only P2 amplitudes showed significant main effects of electrode sites（F=3.51,P〈0.05）.The latency of visual P1,N1 and P2was significantly shorter than the latency of auditory P1,N1 and P2（F=20.45,104.12,107.26;P0.001）;The amplitudes of visual P1 and N1was significantly lower than the amplitudes of auditory P1 and N1（F=7.05,133.82;P〈0.05）.The latency of auditory N2 and P300was significantly longer than the latency of visual N2 and P300（F=52.43,52.64;P〈0.001）.The amplitudes of visual N2 was significantly higher than the amplitudes of auditory N2（F=26.00,P〈0.001）.But there was no difference in the amplitudes of visual P300 and auditory P300（P〉0.05）.Conclusion：Auditory evoked potentials have the following disadvantages：There are many factors that affect the exogenous perception potentials of the early stage.P300 and other advanced endogenous cognitive potentials are relatively stable,but their amplitudes are relatively low.As for visual evoked potentials,exogenous perception potentials of the early stage have a relatively stable result but low amplitudes,but visual advanced endogenous cognitive potent
作者
张萍淑
孔祥慧
元小冬
雷军
王淑娟
吴小英
陶莉
张健
王京
ZHANG Pingshu KONG Xianghui YUAN Xiaodong et al(Department of Neurology ,Affiliated Kailuan General Hospital of North China UniverSity of ScienCe and Technology, Tangshan 063000 ,Chin)
出处
《中国健康心理学杂志》
2017年第1期16-20,共5页
China Journal of Health Psychology
基金
河北省医学适用技术跟踪项目(编号:G2015075)
关键词
视觉诱发电位
听觉诱发电位
P300电位
脑认知功能
外源性感知电位
内源性认知电位
Visual evoked potentials
Auditory evoked potentials
P300potencials
Brai cognitve function
Exogenous perception potentials
Endogenous cognitne potentias
