摘要
目的研究高血压急症患者经持续静脉分别泵入乌拉地尔与硝普钠治疗的血压变化。方法随机选择我院2012年2月~2015年5月收治的高血压急症患者94例,应用随机数字表法分为对照组和研究组,研究组持续静脉泵入乌拉地尔,对照组持续静脉泵入硝普钠,两组各47例,比较两组患者治疗前后的收缩压（SBP）、舒张压（DBP）和心率（HR）变化及不良反应。结果研究组总有效率为93.61%（44/47）,对照组总有效率为76.60%（36/47）,研究组总有效率高于对照组,组间差异有统计学意义（P〈0.05）。研究组出现不良反应3例,对照组10例,两组不良反应发生率差异有统计学意义（P〈0.05）。两组患者的SBP和DBP治疗前后均有下降（P〈0.05）,治疗后,组间SBP和DBP差异无统计学意义（P〉0.05）,组间HR差异有统计学意义（P〈0.05）。结论高血压急症患者经持续静脉泵入乌拉地尔疗效显著,和持续静脉泵入硝普钠相比,临床疗效更加明显,不良反应的发生率降低,有效控制心率。
Objective To investigate the antihypertensive effect of urapidil and sodium nitroprusside in treating hypertension in acute stage. Methods 94 cases of hypertensive emergency patients in our hospital were randomly selected,from February 2012 to May 2015,and divided into two groups. The study group was treated with continuous intravenous infusion of urapidil,the control group with continuous intravenous infusion of sodium nitroprusside,47 cases in each group. The changes of SBP,DBP,HR and adverse drug reaction of the two groups before and after treatment were compared. ResultsThe total antihypertensive effective rate of treatment group was 93.61%（44/47）and control group 76.60%（36/47）. The total effective rate of the treatment group was significantly higher than that of the control group（P〈0. 05）. During the treatment,adverse reactions occurred in 3 cases in treatment group and 10 cases in control group,the incidence of adverse reactions between the two groups was significant（P〈0.05）. And SBP,DBP before and after treatment were significantly decreased in two groups（P〈0.05）. After treatment,there was no significant difference between SBP and DBP in in two groups（P〈0.05）. There was significant difference in HR between two groups（P〈0.05）. Conclusion The antihypertensive efficacy by continuous intravenous infusion of urapidil treatment during hypertensive emergencie is effective and better than that of sodium nitroprusside,the clinical curative effect is more obvious,the incidence of adverse reactions decreased significantly,effective control of the heart rate.
出处
《中国卫生标准管理》
2016年第24期108-110,共3页
China Health Standard Management
关键词
高血压急症
持续静脉泵入
乌拉地尔
硝普钠
临床疗效
Hypertensive emergencies
Continuous intravenous infusion
Urapidil
Sodium nitroprusside
Antihypertensive efficacy
