摘要
脓毒症是心脏术后严重并发症,当发展为脓毒症休克、多脏器功能衰竭时是导致心脏术后患者死亡的重要原因之一。目前,心脏术后脓毒症发病机制尚未明确,有研究表明可能与术中缺血再灌注、体外循环、免疫抑制剂以及手术损伤等原因有关。尽管有药物可调节脓毒症相关的免疫反应,但仍缺乏心脏术后脓毒症治疗的特效药物。该文就心脏手术后脓毒症发生机制及治疗进展进行综述。
Sepsis is one serious complications associated with cardiac surgery,while patients who do develop septic shock and multiple organ failure after cardiac surgery experience a high mortality. The pathogenesis of the cardiac surgery associated sepsis is still unclear. However, research shows that it may be associated with ischemia reperfusion, cardiopulmonary bypass,immunosuppressive therapy,and surgical injury. Although a lot of drugs that could modulate the immunologic response in sepsis,and there are no drugs available that specifically target sepsis. The paper discusses the pathophysiology and management of the sepsis after cardiac surgery.
出处
《职业与健康》
CAS
2016年第23期3301-3304,共4页
Occupation and Health
